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Comparison of biomarkers in serum and induced sputum of patients with occupational asthma and chronic obstructive pulmonary disease

OBJECTIVES: Occupational asthma and chronic obstructive pulmonary disease (COPD) are associated with the airway inflammatory process. The aim of this study was to compare the sputum and serum markers of inflammation in patients with occupational asthma and COPD. METHODS: The study group included 20...

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Autores principales: Kleniewska, Aneta, Walusiak-Skorupa, Jolanta, Piotrowski, Wojciech, Nowakowska-Świrta, Ewa, Wiszniewska, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japan Society for Occupational Health 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356940/
https://www.ncbi.nlm.nih.gov/pubmed/27265531
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author Kleniewska, Aneta
Walusiak-Skorupa, Jolanta
Piotrowski, Wojciech
Nowakowska-Świrta, Ewa
Wiszniewska, Marta
author_facet Kleniewska, Aneta
Walusiak-Skorupa, Jolanta
Piotrowski, Wojciech
Nowakowska-Świrta, Ewa
Wiszniewska, Marta
author_sort Kleniewska, Aneta
collection PubMed
description OBJECTIVES: Occupational asthma and chronic obstructive pulmonary disease (COPD) are associated with the airway inflammatory process. The aim of this study was to compare the sputum and serum markers of inflammation in patients with occupational asthma and COPD. METHODS: The study group included 20 patients with stable COPD, 24 patients with asthma, and 22 healthy subjects. Interleukin (IL)-6, IL-1β, tumor necrosis factor (TNF)-α, matrix metalloproteinase (MMP)-9 levels in serum and induced sputum as well as fibrinogen and CRP in serum were determined in all the subjects. RESULTS: Higher concentrations of IL-1β, IL-6, TNF-α, and MMP-9 in induced sputum and an increased concentration of acute-phase proteins in serum were observed in COPD patients compared with healthy subjects. Higher concentrations of IL-1β and MMP-9 in induced sputum and a higher concentration of C-reactive protein (CRP) were detected in COPD patients than in asthmatic subjects. Never smokers with COPD had significantly higher levels of IL-1β and MMP-9 in induced sputum than never smoker controls. There was no significant difference between the serum and sputum levels of cytokines and MMP-9 of never smokers and smokers with COPD. CONCLUSIONS: Higher concentrations of IL-1β and MMP-9 in induced sputum and a higher concentration of CRP in serum allow distinguishing between biomarker profiles of COPD patients and asthmatic patients. Occupational exposure induces a systemic proinflammatory state with increased levels of acute-phase proteins in stable COPD patients. MMP-9 and IL-1β concentrations are increased in induced sputum of never smokers with COPD, which is associated with occupational exposure.
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spelling pubmed-53569402017-03-23 Comparison of biomarkers in serum and induced sputum of patients with occupational asthma and chronic obstructive pulmonary disease Kleniewska, Aneta Walusiak-Skorupa, Jolanta Piotrowski, Wojciech Nowakowska-Świrta, Ewa Wiszniewska, Marta J Occup Health Original OBJECTIVES: Occupational asthma and chronic obstructive pulmonary disease (COPD) are associated with the airway inflammatory process. The aim of this study was to compare the sputum and serum markers of inflammation in patients with occupational asthma and COPD. METHODS: The study group included 20 patients with stable COPD, 24 patients with asthma, and 22 healthy subjects. Interleukin (IL)-6, IL-1β, tumor necrosis factor (TNF)-α, matrix metalloproteinase (MMP)-9 levels in serum and induced sputum as well as fibrinogen and CRP in serum were determined in all the subjects. RESULTS: Higher concentrations of IL-1β, IL-6, TNF-α, and MMP-9 in induced sputum and an increased concentration of acute-phase proteins in serum were observed in COPD patients compared with healthy subjects. Higher concentrations of IL-1β and MMP-9 in induced sputum and a higher concentration of C-reactive protein (CRP) were detected in COPD patients than in asthmatic subjects. Never smokers with COPD had significantly higher levels of IL-1β and MMP-9 in induced sputum than never smoker controls. There was no significant difference between the serum and sputum levels of cytokines and MMP-9 of never smokers and smokers with COPD. CONCLUSIONS: Higher concentrations of IL-1β and MMP-9 in induced sputum and a higher concentration of CRP in serum allow distinguishing between biomarker profiles of COPD patients and asthmatic patients. Occupational exposure induces a systemic proinflammatory state with increased levels of acute-phase proteins in stable COPD patients. MMP-9 and IL-1β concentrations are increased in induced sputum of never smokers with COPD, which is associated with occupational exposure. Japan Society for Occupational Health 2016-06-06 2016-07-20 /pmc/articles/PMC5356940/ /pubmed/27265531 Text en https://creativecommons.org/licenses/by-nc-sa/4.0/ Journal of Occupational Health is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Original
Kleniewska, Aneta
Walusiak-Skorupa, Jolanta
Piotrowski, Wojciech
Nowakowska-Świrta, Ewa
Wiszniewska, Marta
Comparison of biomarkers in serum and induced sputum of patients with occupational asthma and chronic obstructive pulmonary disease
title Comparison of biomarkers in serum and induced sputum of patients with occupational asthma and chronic obstructive pulmonary disease
title_full Comparison of biomarkers in serum and induced sputum of patients with occupational asthma and chronic obstructive pulmonary disease
title_fullStr Comparison of biomarkers in serum and induced sputum of patients with occupational asthma and chronic obstructive pulmonary disease
title_full_unstemmed Comparison of biomarkers in serum and induced sputum of patients with occupational asthma and chronic obstructive pulmonary disease
title_short Comparison of biomarkers in serum and induced sputum of patients with occupational asthma and chronic obstructive pulmonary disease
title_sort comparison of biomarkers in serum and induced sputum of patients with occupational asthma and chronic obstructive pulmonary disease
topic Original
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356940/
https://www.ncbi.nlm.nih.gov/pubmed/27265531
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