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Respiratory DNA viruses are undetectable in nasopharyngeal secretions from adenotonsillectomized children
Respiratory viruses are frequently detected in association with chronic tonsillar hypertrophy in the absence of symptoms of acute respiratory infection (ARI). The present analysis was done in follow-up to a previous clinical study done by this same group. Nasopharyngeal washes (NPWs) were obtained f...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357011/ https://www.ncbi.nlm.nih.gov/pubmed/28306724 http://dx.doi.org/10.1371/journal.pone.0174188 |
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author | Martins, Ronaldo Bragança Rocha, Lucas Penna Prates, Mirela Moreira Gagliardi, Talita Bianca Biasoli, Balduino Leite, Marcelo Junqueira Buzatto, Guilherme Hyppolito, Miguel Angelo Aragon, Davi Casale Tamashiro, Edwin Valera, Fabiana Cardoso Pereira Arruda, Eurico Anselmo-Lima, Wilma Terezinha |
author_facet | Martins, Ronaldo Bragança Rocha, Lucas Penna Prates, Mirela Moreira Gagliardi, Talita Bianca Biasoli, Balduino Leite, Marcelo Junqueira Buzatto, Guilherme Hyppolito, Miguel Angelo Aragon, Davi Casale Tamashiro, Edwin Valera, Fabiana Cardoso Pereira Arruda, Eurico Anselmo-Lima, Wilma Terezinha |
author_sort | Martins, Ronaldo Bragança |
collection | PubMed |
description | Respiratory viruses are frequently detected in association with chronic tonsillar hypertrophy in the absence of symptoms of acute respiratory infection (ARI). The present analysis was done in follow-up to a previous clinical study done by this same group. Nasopharyngeal washes (NPWs) were obtained from 83 of 120 individuals at variable times post adenotonsillectomy, in the absence of ARI symptoms. A look back at virus detection results in NPWs from the same 83 individuals at the time of tonsillectomy revealed that 73.5% (61/83) were positive for one or more viruses. The overall frequency of respiratory virus detection in post-tonsillectomy NPWs was 58.8%. Rhinovirus (RV) was the agent most frequently detected, in 38 of 83 subjects (45.8%), followed by enterovirus in 7 (8.4%), human metapneumovirus in 6 (7.2%), human respiratory syncytial virus in 3 (3.6%) and human coronavirus in 1 (1.2%). Remarkably, there was no detection of adenovirus (HAdV) or human bocavirus (HBoV) in asymptomatic individuals in follow-up of adenotonsillectomy. In keeping with persistence of respiratory DNA viruses in human tonsils, tonsillectomy significantly reduces asymptomatic shedding of HAdV and HBoV in NPWs. |
format | Online Article Text |
id | pubmed-5357011 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-53570112017-03-30 Respiratory DNA viruses are undetectable in nasopharyngeal secretions from adenotonsillectomized children Martins, Ronaldo Bragança Rocha, Lucas Penna Prates, Mirela Moreira Gagliardi, Talita Bianca Biasoli, Balduino Leite, Marcelo Junqueira Buzatto, Guilherme Hyppolito, Miguel Angelo Aragon, Davi Casale Tamashiro, Edwin Valera, Fabiana Cardoso Pereira Arruda, Eurico Anselmo-Lima, Wilma Terezinha PLoS One Research Article Respiratory viruses are frequently detected in association with chronic tonsillar hypertrophy in the absence of symptoms of acute respiratory infection (ARI). The present analysis was done in follow-up to a previous clinical study done by this same group. Nasopharyngeal washes (NPWs) were obtained from 83 of 120 individuals at variable times post adenotonsillectomy, in the absence of ARI symptoms. A look back at virus detection results in NPWs from the same 83 individuals at the time of tonsillectomy revealed that 73.5% (61/83) were positive for one or more viruses. The overall frequency of respiratory virus detection in post-tonsillectomy NPWs was 58.8%. Rhinovirus (RV) was the agent most frequently detected, in 38 of 83 subjects (45.8%), followed by enterovirus in 7 (8.4%), human metapneumovirus in 6 (7.2%), human respiratory syncytial virus in 3 (3.6%) and human coronavirus in 1 (1.2%). Remarkably, there was no detection of adenovirus (HAdV) or human bocavirus (HBoV) in asymptomatic individuals in follow-up of adenotonsillectomy. In keeping with persistence of respiratory DNA viruses in human tonsils, tonsillectomy significantly reduces asymptomatic shedding of HAdV and HBoV in NPWs. Public Library of Science 2017-03-17 /pmc/articles/PMC5357011/ /pubmed/28306724 http://dx.doi.org/10.1371/journal.pone.0174188 Text en © 2017 Martins et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Martins, Ronaldo Bragança Rocha, Lucas Penna Prates, Mirela Moreira Gagliardi, Talita Bianca Biasoli, Balduino Leite, Marcelo Junqueira Buzatto, Guilherme Hyppolito, Miguel Angelo Aragon, Davi Casale Tamashiro, Edwin Valera, Fabiana Cardoso Pereira Arruda, Eurico Anselmo-Lima, Wilma Terezinha Respiratory DNA viruses are undetectable in nasopharyngeal secretions from adenotonsillectomized children |
title | Respiratory DNA viruses are undetectable in nasopharyngeal secretions from adenotonsillectomized children |
title_full | Respiratory DNA viruses are undetectable in nasopharyngeal secretions from adenotonsillectomized children |
title_fullStr | Respiratory DNA viruses are undetectable in nasopharyngeal secretions from adenotonsillectomized children |
title_full_unstemmed | Respiratory DNA viruses are undetectable in nasopharyngeal secretions from adenotonsillectomized children |
title_short | Respiratory DNA viruses are undetectable in nasopharyngeal secretions from adenotonsillectomized children |
title_sort | respiratory dna viruses are undetectable in nasopharyngeal secretions from adenotonsillectomized children |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357011/ https://www.ncbi.nlm.nih.gov/pubmed/28306724 http://dx.doi.org/10.1371/journal.pone.0174188 |
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