New microbial source of the antifungal allylamine “Terbinafine”

The isolated active compound “F12” from the culture media of the Streptomyces sp. KH-F12 was identified using different spectroscopic techniques. Both 1D- and 2D-NMR as well as HRESIMS were utilized to characterize the structure of the isolated compound. ‘F12” was found to be the known systemic anti...

Descripción completa

Detalles Bibliográficos
Autores principales: Abdel-Kader, Maged S., Muharram, Magdy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357105/
https://www.ncbi.nlm.nih.gov/pubmed/28344499
http://dx.doi.org/10.1016/j.jsps.2016.06.006
_version_ 1782515985832476672
author Abdel-Kader, Maged S.
Muharram, Magdy M.
author_facet Abdel-Kader, Maged S.
Muharram, Magdy M.
author_sort Abdel-Kader, Maged S.
collection PubMed
description The isolated active compound “F12” from the culture media of the Streptomyces sp. KH-F12 was identified using different spectroscopic techniques. Both 1D- and 2D-NMR as well as HRESIMS were utilized to characterize the structure of the isolated compound. ‘F12” was found to be the known systemic antifungal drug terbinafine marketed under the name “Lamisil”. Full analysis of the COSY, HSQC and HMBC enables the full assignment of proton and carbon atoms. Terbinafine is a synthetic allylamine and is reported here for the first time from natural source.
format Online
Article
Text
id pubmed-5357105
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-53571052017-03-24 New microbial source of the antifungal allylamine “Terbinafine” Abdel-Kader, Maged S. Muharram, Magdy M. Saudi Pharm J Short Communication The isolated active compound “F12” from the culture media of the Streptomyces sp. KH-F12 was identified using different spectroscopic techniques. Both 1D- and 2D-NMR as well as HRESIMS were utilized to characterize the structure of the isolated compound. ‘F12” was found to be the known systemic antifungal drug terbinafine marketed under the name “Lamisil”. Full analysis of the COSY, HSQC and HMBC enables the full assignment of proton and carbon atoms. Terbinafine is a synthetic allylamine and is reported here for the first time from natural source. Elsevier 2017-03 2016-06-24 /pmc/articles/PMC5357105/ /pubmed/28344499 http://dx.doi.org/10.1016/j.jsps.2016.06.006 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Short Communication
Abdel-Kader, Maged S.
Muharram, Magdy M.
New microbial source of the antifungal allylamine “Terbinafine”
title New microbial source of the antifungal allylamine “Terbinafine”
title_full New microbial source of the antifungal allylamine “Terbinafine”
title_fullStr New microbial source of the antifungal allylamine “Terbinafine”
title_full_unstemmed New microbial source of the antifungal allylamine “Terbinafine”
title_short New microbial source of the antifungal allylamine “Terbinafine”
title_sort new microbial source of the antifungal allylamine “terbinafine”
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357105/
https://www.ncbi.nlm.nih.gov/pubmed/28344499
http://dx.doi.org/10.1016/j.jsps.2016.06.006
work_keys_str_mv AT abdelkadermageds newmicrobialsourceoftheantifungalallylamineterbinafine
AT muharrammagdym newmicrobialsourceoftheantifungalallylamineterbinafine

Ejemplares similares