Sorting receptor SORLA: cellular mechanisms and implications for disease

Sorting-related receptor with A-type repeats (SORLA) is an intracellular sorting receptor that directs cargo proteins, such as kinases, phosphatases, and signaling receptors, to their correct location within the cell. The activity of SORLA assures proper function of cells and tissues, and receptor d...

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Detalles Bibliográficos
Autores principales: Schmidt, Vanessa, Subkhangulova, Aygul, Willnow, Thomas E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357279/
https://www.ncbi.nlm.nih.gov/pubmed/27832290
http://dx.doi.org/10.1007/s00018-016-2410-z
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author Schmidt, Vanessa
Subkhangulova, Aygul
Willnow, Thomas E.
author_facet Schmidt, Vanessa
Subkhangulova, Aygul
Willnow, Thomas E.
author_sort Schmidt, Vanessa
collection PubMed
description Sorting-related receptor with A-type repeats (SORLA) is an intracellular sorting receptor that directs cargo proteins, such as kinases, phosphatases, and signaling receptors, to their correct location within the cell. The activity of SORLA assures proper function of cells and tissues, and receptor dysfunction is the underlying cause of common human malignancies, including Alzheimer’s disease, atherosclerosis, and obesity. Here, we discuss the molecular mechanisms that govern sorting of SORLA and its cargo in multiple cell types, and why genetic defects in this receptor results in devastating diseases.
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spelling pubmed-53572792017-03-30 Sorting receptor SORLA: cellular mechanisms and implications for disease Schmidt, Vanessa Subkhangulova, Aygul Willnow, Thomas E. Cell Mol Life Sci Review Sorting-related receptor with A-type repeats (SORLA) is an intracellular sorting receptor that directs cargo proteins, such as kinases, phosphatases, and signaling receptors, to their correct location within the cell. The activity of SORLA assures proper function of cells and tissues, and receptor dysfunction is the underlying cause of common human malignancies, including Alzheimer’s disease, atherosclerosis, and obesity. Here, we discuss the molecular mechanisms that govern sorting of SORLA and its cargo in multiple cell types, and why genetic defects in this receptor results in devastating diseases. Springer International Publishing 2016-11-10 2017 /pmc/articles/PMC5357279/ /pubmed/27832290 http://dx.doi.org/10.1007/s00018-016-2410-z Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Schmidt, Vanessa
Subkhangulova, Aygul
Willnow, Thomas E.
Sorting receptor SORLA: cellular mechanisms and implications for disease
title Sorting receptor SORLA: cellular mechanisms and implications for disease
title_full Sorting receptor SORLA: cellular mechanisms and implications for disease
title_fullStr Sorting receptor SORLA: cellular mechanisms and implications for disease
title_full_unstemmed Sorting receptor SORLA: cellular mechanisms and implications for disease
title_short Sorting receptor SORLA: cellular mechanisms and implications for disease
title_sort sorting receptor sorla: cellular mechanisms and implications for disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357279/
https://www.ncbi.nlm.nih.gov/pubmed/27832290
http://dx.doi.org/10.1007/s00018-016-2410-z
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AT subkhangulovaaygul sortingreceptorsorlacellularmechanismsandimplicationsfordisease
AT willnowthomase sortingreceptorsorlacellularmechanismsandimplicationsfordisease

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