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Cardiomyocyte proliferation in zebrafish and mammals: lessons for human disease

Cardiomyocytes proliferate profusely during early development and for a brief period after birth in mammals. Within a month after birth, this proliferative capability is dramatically reduced in mammals unlike lower vertebrates where it persists into adult life. The zebrafish, for example, retains th...

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Autores principales: Matrone, Gianfranco, Tucker, Carl S., Denvir, Martin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357290/
https://www.ncbi.nlm.nih.gov/pubmed/27812722
http://dx.doi.org/10.1007/s00018-016-2404-x
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author Matrone, Gianfranco
Tucker, Carl S.
Denvir, Martin A.
author_facet Matrone, Gianfranco
Tucker, Carl S.
Denvir, Martin A.
author_sort Matrone, Gianfranco
collection PubMed
description Cardiomyocytes proliferate profusely during early development and for a brief period after birth in mammals. Within a month after birth, this proliferative capability is dramatically reduced in mammals unlike lower vertebrates where it persists into adult life. The zebrafish, for example, retains the ability to regenerate the apex of the heart following resection by a mechanism predominantly driven by cardiomyocyte proliferation. Differences in proliferative capacity of cardiomyocytes in adulthood between mammals and lower vertebrates are closely liked to ontogenetic or phylogenetic factors. Elucidation of these factors has the potential to provide enormous benefits if they lead to the development of therapeutic strategies that facilitate cardiomyocyte proliferation. In this review, we highlight the differences between Mammalian and Zebrafish cardiomyocytes, which could explain at least in part the different proliferative capacities in these two species. We discuss the advantages of the zebrafish as a model of cardiomyocyte proliferation, particularly at the embryonic stage. We also identify a number of key molecular pathways with potential to reveal key steps in switching cardiomyocytes from a quiescent to a proliferative phenotype. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00018-016-2404-x) contains supplementary material, which is available to authorized users.
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spelling pubmed-53572902017-03-30 Cardiomyocyte proliferation in zebrafish and mammals: lessons for human disease Matrone, Gianfranco Tucker, Carl S. Denvir, Martin A. Cell Mol Life Sci Review Cardiomyocytes proliferate profusely during early development and for a brief period after birth in mammals. Within a month after birth, this proliferative capability is dramatically reduced in mammals unlike lower vertebrates where it persists into adult life. The zebrafish, for example, retains the ability to regenerate the apex of the heart following resection by a mechanism predominantly driven by cardiomyocyte proliferation. Differences in proliferative capacity of cardiomyocytes in adulthood between mammals and lower vertebrates are closely liked to ontogenetic or phylogenetic factors. Elucidation of these factors has the potential to provide enormous benefits if they lead to the development of therapeutic strategies that facilitate cardiomyocyte proliferation. In this review, we highlight the differences between Mammalian and Zebrafish cardiomyocytes, which could explain at least in part the different proliferative capacities in these two species. We discuss the advantages of the zebrafish as a model of cardiomyocyte proliferation, particularly at the embryonic stage. We also identify a number of key molecular pathways with potential to reveal key steps in switching cardiomyocytes from a quiescent to a proliferative phenotype. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00018-016-2404-x) contains supplementary material, which is available to authorized users. Springer International Publishing 2016-11-03 2017 /pmc/articles/PMC5357290/ /pubmed/27812722 http://dx.doi.org/10.1007/s00018-016-2404-x Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Matrone, Gianfranco
Tucker, Carl S.
Denvir, Martin A.
Cardiomyocyte proliferation in zebrafish and mammals: lessons for human disease
title Cardiomyocyte proliferation in zebrafish and mammals: lessons for human disease
title_full Cardiomyocyte proliferation in zebrafish and mammals: lessons for human disease
title_fullStr Cardiomyocyte proliferation in zebrafish and mammals: lessons for human disease
title_full_unstemmed Cardiomyocyte proliferation in zebrafish and mammals: lessons for human disease
title_short Cardiomyocyte proliferation in zebrafish and mammals: lessons for human disease
title_sort cardiomyocyte proliferation in zebrafish and mammals: lessons for human disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357290/
https://www.ncbi.nlm.nih.gov/pubmed/27812722
http://dx.doi.org/10.1007/s00018-016-2404-x
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