A novel 72-kDa leukocyte-derived osteoglycin enhances the activation of toll-like receptor 4 and exacerbates cardiac inflammation during viral myocarditis

BACKGROUND: Viral myocarditis can severely damage the myocardium through excessive infiltration of immune cells. Osteoglycin (OGN) is part of the small leucine-rich repeat proteoglycan (SLRP) family. SLRP’s may affect inflammatory and fibrotic processes, but the implication of OGN in cardiac inflamm...

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Detalles Bibliográficos
Autores principales: Rienks, Marieke, Papageorgiou, Anna, Wouters, Kristiaan, Verhesen, Wouter, Leeuwen, Rick van, Carai, Paolo, Summer, Georg, Westermann, Dirk, Heymans, Stephane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357299/
https://www.ncbi.nlm.nih.gov/pubmed/27878326
http://dx.doi.org/10.1007/s00018-016-2423-7

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