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Targeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment
The Wnt, Hedgehog, and Notch pathways are inherent signaling pathways in normal embryogenesis, development, and hemostasis. However, dysfunctions of these pathways are evident in multiple tumor types and malignancies. Specifically, aberrant activation of these pathways is implicated in modulation of...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357538/ https://www.ncbi.nlm.nih.gov/pubmed/28356914 http://dx.doi.org/10.1155/2017/2925869 |
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author | Koury, Jeffrey Zhong, Li Hao, Jijun |
author_facet | Koury, Jeffrey Zhong, Li Hao, Jijun |
author_sort | Koury, Jeffrey |
collection | PubMed |
description | The Wnt, Hedgehog, and Notch pathways are inherent signaling pathways in normal embryogenesis, development, and hemostasis. However, dysfunctions of these pathways are evident in multiple tumor types and malignancies. Specifically, aberrant activation of these pathways is implicated in modulation of cancer stem cells (CSCs), a small subset of cancer cells capable of self-renewal and differentiation into heterogeneous tumor cells. The CSCs are accountable for tumor initiation, growth, and recurrence. In this review, we focus on roles of Wnt, Hedgehog, and Notch pathways in CSCs' stemness and functions and summarize therapeutic studies targeting these pathways to eliminate CSCs and improve overall cancer treatment outcomes. |
format | Online Article Text |
id | pubmed-5357538 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-53575382017-03-29 Targeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment Koury, Jeffrey Zhong, Li Hao, Jijun Stem Cells Int Review Article The Wnt, Hedgehog, and Notch pathways are inherent signaling pathways in normal embryogenesis, development, and hemostasis. However, dysfunctions of these pathways are evident in multiple tumor types and malignancies. Specifically, aberrant activation of these pathways is implicated in modulation of cancer stem cells (CSCs), a small subset of cancer cells capable of self-renewal and differentiation into heterogeneous tumor cells. The CSCs are accountable for tumor initiation, growth, and recurrence. In this review, we focus on roles of Wnt, Hedgehog, and Notch pathways in CSCs' stemness and functions and summarize therapeutic studies targeting these pathways to eliminate CSCs and improve overall cancer treatment outcomes. Hindawi 2017 2017-03-05 /pmc/articles/PMC5357538/ /pubmed/28356914 http://dx.doi.org/10.1155/2017/2925869 Text en Copyright © 2017 Jeffrey Koury et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Koury, Jeffrey Zhong, Li Hao, Jijun Targeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment |
title | Targeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment |
title_full | Targeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment |
title_fullStr | Targeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment |
title_full_unstemmed | Targeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment |
title_short | Targeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment |
title_sort | targeting signaling pathways in cancer stem cells for cancer treatment |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357538/ https://www.ncbi.nlm.nih.gov/pubmed/28356914 http://dx.doi.org/10.1155/2017/2925869 |
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