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Targeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment

The Wnt, Hedgehog, and Notch pathways are inherent signaling pathways in normal embryogenesis, development, and hemostasis. However, dysfunctions of these pathways are evident in multiple tumor types and malignancies. Specifically, aberrant activation of these pathways is implicated in modulation of...

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Detalles Bibliográficos
Autores principales: Koury, Jeffrey, Zhong, Li, Hao, Jijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357538/
https://www.ncbi.nlm.nih.gov/pubmed/28356914
http://dx.doi.org/10.1155/2017/2925869
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author Koury, Jeffrey
Zhong, Li
Hao, Jijun
author_facet Koury, Jeffrey
Zhong, Li
Hao, Jijun
author_sort Koury, Jeffrey
collection PubMed
description The Wnt, Hedgehog, and Notch pathways are inherent signaling pathways in normal embryogenesis, development, and hemostasis. However, dysfunctions of these pathways are evident in multiple tumor types and malignancies. Specifically, aberrant activation of these pathways is implicated in modulation of cancer stem cells (CSCs), a small subset of cancer cells capable of self-renewal and differentiation into heterogeneous tumor cells. The CSCs are accountable for tumor initiation, growth, and recurrence. In this review, we focus on roles of Wnt, Hedgehog, and Notch pathways in CSCs' stemness and functions and summarize therapeutic studies targeting these pathways to eliminate CSCs and improve overall cancer treatment outcomes.
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spelling pubmed-53575382017-03-29 Targeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment Koury, Jeffrey Zhong, Li Hao, Jijun Stem Cells Int Review Article The Wnt, Hedgehog, and Notch pathways are inherent signaling pathways in normal embryogenesis, development, and hemostasis. However, dysfunctions of these pathways are evident in multiple tumor types and malignancies. Specifically, aberrant activation of these pathways is implicated in modulation of cancer stem cells (CSCs), a small subset of cancer cells capable of self-renewal and differentiation into heterogeneous tumor cells. The CSCs are accountable for tumor initiation, growth, and recurrence. In this review, we focus on roles of Wnt, Hedgehog, and Notch pathways in CSCs' stemness and functions and summarize therapeutic studies targeting these pathways to eliminate CSCs and improve overall cancer treatment outcomes. Hindawi 2017 2017-03-05 /pmc/articles/PMC5357538/ /pubmed/28356914 http://dx.doi.org/10.1155/2017/2925869 Text en Copyright © 2017 Jeffrey Koury et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Koury, Jeffrey
Zhong, Li
Hao, Jijun
Targeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment
title Targeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment
title_full Targeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment
title_fullStr Targeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment
title_full_unstemmed Targeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment
title_short Targeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment
title_sort targeting signaling pathways in cancer stem cells for cancer treatment
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357538/
https://www.ncbi.nlm.nih.gov/pubmed/28356914
http://dx.doi.org/10.1155/2017/2925869
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