Altered Mitochondrial Signalling and Metabolism in Cancer

Mitochondria being the central organelle for metabolism and other cell signalling pathways have remained the topic of interest to tumour biologists. In spite of the wide acceptance of Warburg’s hypothesis, role of mitochondrial metabolism in cancer is still unclear. Uncontrolled growth and prolifera...

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Detalles Bibliográficos
Autores principales: Chattopadhyay, Esita, Roy, Bidyut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357656/
https://www.ncbi.nlm.nih.gov/pubmed/28373964
http://dx.doi.org/10.3389/fonc.2017.00043
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author Chattopadhyay, Esita
Roy, Bidyut
author_facet Chattopadhyay, Esita
Roy, Bidyut
author_sort Chattopadhyay, Esita
collection PubMed
description Mitochondria being the central organelle for metabolism and other cell signalling pathways have remained the topic of interest to tumour biologists. In spite of the wide acceptance of Warburg’s hypothesis, role of mitochondrial metabolism in cancer is still unclear. Uncontrolled growth and proliferation, hallmarks of tumour cells, are maintained when the cells adapt to metabolic reprogramming with the help of altered metabolism of mitochondria. This review has focussed on different aspects of mitochondrial metabolism and inter-related signalling pathways which have been found to be modified in cancer.
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spelling pubmed-53576562017-04-03 Altered Mitochondrial Signalling and Metabolism in Cancer Chattopadhyay, Esita Roy, Bidyut Front Oncol Oncology Mitochondria being the central organelle for metabolism and other cell signalling pathways have remained the topic of interest to tumour biologists. In spite of the wide acceptance of Warburg’s hypothesis, role of mitochondrial metabolism in cancer is still unclear. Uncontrolled growth and proliferation, hallmarks of tumour cells, are maintained when the cells adapt to metabolic reprogramming with the help of altered metabolism of mitochondria. This review has focussed on different aspects of mitochondrial metabolism and inter-related signalling pathways which have been found to be modified in cancer. Frontiers Media S.A. 2017-03-20 /pmc/articles/PMC5357656/ /pubmed/28373964 http://dx.doi.org/10.3389/fonc.2017.00043 Text en Copyright © 2017 Chattopadhyay and Roy. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Chattopadhyay, Esita
Roy, Bidyut
Altered Mitochondrial Signalling and Metabolism in Cancer
title Altered Mitochondrial Signalling and Metabolism in Cancer
title_full Altered Mitochondrial Signalling and Metabolism in Cancer
title_fullStr Altered Mitochondrial Signalling and Metabolism in Cancer
title_full_unstemmed Altered Mitochondrial Signalling and Metabolism in Cancer
title_short Altered Mitochondrial Signalling and Metabolism in Cancer
title_sort altered mitochondrial signalling and metabolism in cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357656/
https://www.ncbi.nlm.nih.gov/pubmed/28373964
http://dx.doi.org/10.3389/fonc.2017.00043
work_keys_str_mv AT chattopadhyayesita alteredmitochondrialsignallingandmetabolismincancer
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