Mitochondrial hyperpolarization in iPSC-derived neurons from patients of FTDP-17 with 10+16 MAPT mutation leads to oxidative stress and neurodegeneration

Tau protein inclusions are a frequent hallmark of a variety of neurodegenerative disorders. The 10+16 intronic mutation in MAPT gene, encoding tau, causes frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), by altering the splicing of the gene and inducing an increase in the...

Descripción completa

Detalles Bibliográficos
Autores principales: Esteras, Noemí, Rohrer, Jonathan D., Hardy, John, Wray, Selina, Abramov, Andrey Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357682/
https://www.ncbi.nlm.nih.gov/pubmed/28319892
http://dx.doi.org/10.1016/j.redox.2017.03.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357682/
https://www.ncbi.nlm.nih.gov/pubmed/28319892
http://dx.doi.org/10.1016/j.redox.2017.03.008

Ejemplares similares