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Comprehensive genomic profiling (CGP) of ovarian clear cell carcinomas (OCCC) identifies clinically relevant genomic alterations (CRGA) and targeted therapy options
• MTOR pathway genes are often mutated in ovarian clear cell carcinomas (OCCC). • 11.2% of OCCC have targetable alterations only in the mTOR pathway. • MTOR pathway mutations in OCCC can underlie robust, lasting responses to everolimus.
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357688/ https://www.ncbi.nlm.nih.gov/pubmed/28349114 http://dx.doi.org/10.1016/j.gore.2017.02.007 |