CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in cerebral organoids derived from iPS cells

BACKGROUND: CHD8 (chromodomain helicase DNA-binding protein 8), which codes for a member of the CHD family of ATP-dependent chromatin-remodeling factors, is one of the most commonly mutated genes in autism spectrum disorders (ASD) identified in exome-sequencing studies. Loss of function mutations in...

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Detalles Bibliográficos
Autores principales: Wang, Ping, Mokhtari, Ryan, Pedrosa, Erika, Kirschenbaum, Michael, Bayrak, Can, Zheng, Deyou, Lachman, Herbert M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357816/
https://www.ncbi.nlm.nih.gov/pubmed/28321286
http://dx.doi.org/10.1186/s13229-017-0124-1

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