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Absence of renal enlargement in fructose‐fed proximal‐tubule‐select insulin receptor (IR), insulin‐like‐growth factor receptor (IGF1R) double knockout mice

The major site of fructose metabolism in the kidney is the proximal tubule (PT). To test whether insulin and/or IGF1 signaling in the PT is involved in renal structural/functional responses to dietary fructose, we bred mice with dual knockout (KO) of the insulin receptor (IR) and the IGF1 receptor (...

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Detalles Bibliográficos
Autores principales:	Li, Lijun, Byrd, Marcus, Doh, Kwame, Dixon, Patrice D., Lee, Hwal, Tiwari, Swasti, Ecelbarger, Carolyn M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357825/ https://www.ncbi.nlm.nih.gov/pubmed/27923977 http://dx.doi.org/10.14814/phy2.13052

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