DEK is required for homologous recombination repair of DNA breaks

DEK is a highly conserved chromatin-bound protein whose upregulation across cancer types correlates with genotoxic therapy resistance. Loss of DEK induces genome instability and sensitizes cells to DNA double strand breaks (DSBs), suggesting defects in DNA repair. While these DEK-deficiency phenotyp...

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Detalles Bibliográficos
Autores principales: Smith, Eric A., Gole, Boris, Willis, Nicholas A., Soria, Rebeca, Starnes, Linda M., Krumpelbeck, Eric F., Jegga, Anil G., Ali, Abdullah M., Guo, Haihong, Meetei, Amom R., Andreassen, Paul R., Kappes, Ferdinand, Vinnedge, Lisa M. Privette, Daniel, Jeremy A., Scully, Ralph, Wiesmüller, Lisa, Wells, Susanne I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357905/
https://www.ncbi.nlm.nih.gov/pubmed/28317934
http://dx.doi.org/10.1038/srep44662

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