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Early Versus Late Onset of Cannabis Use: Differences in Striatal Response to Cannabis Cues

Addiction theories posit that addiction is the result of a progressive transition from voluntary to habitual, compulsive drug use—changes that have been linked, in animals, to a shift from ventral to dorsal striatal control over drug-seeking behavior. Thus, we hypothesized that early-onset (EOs) can...

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Autores principales: Wetherill, Reagan R., Hager, Nathan, Jagannathan, Kanchana, Mashhoon, Yasmin, Pater, Heather, Childress, Anna Rose, Franklin, Teresa R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358095/
https://www.ncbi.nlm.nih.gov/pubmed/28331903
http://dx.doi.org/10.1089/can.2016.0026
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author Wetherill, Reagan R.
Hager, Nathan
Jagannathan, Kanchana
Mashhoon, Yasmin
Pater, Heather
Childress, Anna Rose
Franklin, Teresa R.
author_facet Wetherill, Reagan R.
Hager, Nathan
Jagannathan, Kanchana
Mashhoon, Yasmin
Pater, Heather
Childress, Anna Rose
Franklin, Teresa R.
author_sort Wetherill, Reagan R.
collection PubMed
description Addiction theories posit that addiction is the result of a progressive transition from voluntary to habitual, compulsive drug use—changes that have been linked, in animals, to a shift from ventral to dorsal striatal control over drug-seeking behavior. Thus, we hypothesized that early-onset (EOs) cannabis users versus late-onset (LOs) cannabis users might exhibit, respectively, greater dorsal versus ventral striatal response to drug cues. We used functional magnetic resonance imaging and an event-related blood oxygen level-dependent backward-masking task to evaluate striatal responses to backward-masked cannabis cues (vs. neutral cues) in EOs (<16 years old, n=15) and LOs (≥16 years old, n=26) with similar recent cannabis use patterns. Direct comparisons revealed that EOs showed greater response to cannabis cues in the dorsal striatum than LOs (p<0.01, k>50 voxels). Within-group analyses revealed that EOs showed greater neural response to cannabis cues in the dorsal striatum, whereas LOs exhibited greater neural response to cannabis cues in the ventral striatum. Although cross-sectional, these findings are consistent with recent addiction theories suggesting a progressive shift from ventral to dorsal striatal control over drug-seeking behavior and highlight the importance of age of onset of cannabis use on the brain and cognition.
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spelling pubmed-53580952017-03-20 Early Versus Late Onset of Cannabis Use: Differences in Striatal Response to Cannabis Cues Wetherill, Reagan R. Hager, Nathan Jagannathan, Kanchana Mashhoon, Yasmin Pater, Heather Childress, Anna Rose Franklin, Teresa R. Cannabis Cannabinoid Res Rapid Communication Addiction theories posit that addiction is the result of a progressive transition from voluntary to habitual, compulsive drug use—changes that have been linked, in animals, to a shift from ventral to dorsal striatal control over drug-seeking behavior. Thus, we hypothesized that early-onset (EOs) cannabis users versus late-onset (LOs) cannabis users might exhibit, respectively, greater dorsal versus ventral striatal response to drug cues. We used functional magnetic resonance imaging and an event-related blood oxygen level-dependent backward-masking task to evaluate striatal responses to backward-masked cannabis cues (vs. neutral cues) in EOs (<16 years old, n=15) and LOs (≥16 years old, n=26) with similar recent cannabis use patterns. Direct comparisons revealed that EOs showed greater response to cannabis cues in the dorsal striatum than LOs (p<0.01, k>50 voxels). Within-group analyses revealed that EOs showed greater neural response to cannabis cues in the dorsal striatum, whereas LOs exhibited greater neural response to cannabis cues in the ventral striatum. Although cross-sectional, these findings are consistent with recent addiction theories suggesting a progressive shift from ventral to dorsal striatal control over drug-seeking behavior and highlight the importance of age of onset of cannabis use on the brain and cognition. Mary Ann Liebert, Inc. 2016-10-01 /pmc/articles/PMC5358095/ /pubmed/28331903 http://dx.doi.org/10.1089/can.2016.0026 Text en © Reagan R. Wetherill et al. 2016; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Rapid Communication
Wetherill, Reagan R.
Hager, Nathan
Jagannathan, Kanchana
Mashhoon, Yasmin
Pater, Heather
Childress, Anna Rose
Franklin, Teresa R.
Early Versus Late Onset of Cannabis Use: Differences in Striatal Response to Cannabis Cues
title Early Versus Late Onset of Cannabis Use: Differences in Striatal Response to Cannabis Cues
title_full Early Versus Late Onset of Cannabis Use: Differences in Striatal Response to Cannabis Cues
title_fullStr Early Versus Late Onset of Cannabis Use: Differences in Striatal Response to Cannabis Cues
title_full_unstemmed Early Versus Late Onset of Cannabis Use: Differences in Striatal Response to Cannabis Cues
title_short Early Versus Late Onset of Cannabis Use: Differences in Striatal Response to Cannabis Cues
title_sort early versus late onset of cannabis use: differences in striatal response to cannabis cues
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358095/
https://www.ncbi.nlm.nih.gov/pubmed/28331903
http://dx.doi.org/10.1089/can.2016.0026
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