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Early Versus Late Onset of Cannabis Use: Differences in Striatal Response to Cannabis Cues
Addiction theories posit that addiction is the result of a progressive transition from voluntary to habitual, compulsive drug use—changes that have been linked, in animals, to a shift from ventral to dorsal striatal control over drug-seeking behavior. Thus, we hypothesized that early-onset (EOs) can...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Mary Ann Liebert, Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358095/ https://www.ncbi.nlm.nih.gov/pubmed/28331903 http://dx.doi.org/10.1089/can.2016.0026 |
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author | Wetherill, Reagan R. Hager, Nathan Jagannathan, Kanchana Mashhoon, Yasmin Pater, Heather Childress, Anna Rose Franklin, Teresa R. |
author_facet | Wetherill, Reagan R. Hager, Nathan Jagannathan, Kanchana Mashhoon, Yasmin Pater, Heather Childress, Anna Rose Franklin, Teresa R. |
author_sort | Wetherill, Reagan R. |
collection | PubMed |
description | Addiction theories posit that addiction is the result of a progressive transition from voluntary to habitual, compulsive drug use—changes that have been linked, in animals, to a shift from ventral to dorsal striatal control over drug-seeking behavior. Thus, we hypothesized that early-onset (EOs) cannabis users versus late-onset (LOs) cannabis users might exhibit, respectively, greater dorsal versus ventral striatal response to drug cues. We used functional magnetic resonance imaging and an event-related blood oxygen level-dependent backward-masking task to evaluate striatal responses to backward-masked cannabis cues (vs. neutral cues) in EOs (<16 years old, n=15) and LOs (≥16 years old, n=26) with similar recent cannabis use patterns. Direct comparisons revealed that EOs showed greater response to cannabis cues in the dorsal striatum than LOs (p<0.01, k>50 voxels). Within-group analyses revealed that EOs showed greater neural response to cannabis cues in the dorsal striatum, whereas LOs exhibited greater neural response to cannabis cues in the ventral striatum. Although cross-sectional, these findings are consistent with recent addiction theories suggesting a progressive shift from ventral to dorsal striatal control over drug-seeking behavior and highlight the importance of age of onset of cannabis use on the brain and cognition. |
format | Online Article Text |
id | pubmed-5358095 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Mary Ann Liebert, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-53580952017-03-20 Early Versus Late Onset of Cannabis Use: Differences in Striatal Response to Cannabis Cues Wetherill, Reagan R. Hager, Nathan Jagannathan, Kanchana Mashhoon, Yasmin Pater, Heather Childress, Anna Rose Franklin, Teresa R. Cannabis Cannabinoid Res Rapid Communication Addiction theories posit that addiction is the result of a progressive transition from voluntary to habitual, compulsive drug use—changes that have been linked, in animals, to a shift from ventral to dorsal striatal control over drug-seeking behavior. Thus, we hypothesized that early-onset (EOs) cannabis users versus late-onset (LOs) cannabis users might exhibit, respectively, greater dorsal versus ventral striatal response to drug cues. We used functional magnetic resonance imaging and an event-related blood oxygen level-dependent backward-masking task to evaluate striatal responses to backward-masked cannabis cues (vs. neutral cues) in EOs (<16 years old, n=15) and LOs (≥16 years old, n=26) with similar recent cannabis use patterns. Direct comparisons revealed that EOs showed greater response to cannabis cues in the dorsal striatum than LOs (p<0.01, k>50 voxels). Within-group analyses revealed that EOs showed greater neural response to cannabis cues in the dorsal striatum, whereas LOs exhibited greater neural response to cannabis cues in the ventral striatum. Although cross-sectional, these findings are consistent with recent addiction theories suggesting a progressive shift from ventral to dorsal striatal control over drug-seeking behavior and highlight the importance of age of onset of cannabis use on the brain and cognition. Mary Ann Liebert, Inc. 2016-10-01 /pmc/articles/PMC5358095/ /pubmed/28331903 http://dx.doi.org/10.1089/can.2016.0026 Text en © Reagan R. Wetherill et al. 2016; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. |
spellingShingle | Rapid Communication Wetherill, Reagan R. Hager, Nathan Jagannathan, Kanchana Mashhoon, Yasmin Pater, Heather Childress, Anna Rose Franklin, Teresa R. Early Versus Late Onset of Cannabis Use: Differences in Striatal Response to Cannabis Cues |
title | Early Versus Late Onset of Cannabis Use: Differences in Striatal Response to Cannabis Cues |
title_full | Early Versus Late Onset of Cannabis Use: Differences in Striatal Response to Cannabis Cues |
title_fullStr | Early Versus Late Onset of Cannabis Use: Differences in Striatal Response to Cannabis Cues |
title_full_unstemmed | Early Versus Late Onset of Cannabis Use: Differences in Striatal Response to Cannabis Cues |
title_short | Early Versus Late Onset of Cannabis Use: Differences in Striatal Response to Cannabis Cues |
title_sort | early versus late onset of cannabis use: differences in striatal response to cannabis cues |
topic | Rapid Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358095/ https://www.ncbi.nlm.nih.gov/pubmed/28331903 http://dx.doi.org/10.1089/can.2016.0026 |
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