Application of methods of identifying receptor binding models and analysis of parameters

BACKGROUND: Possible methods for distinguishing receptor binding models and analysing their parameters are considered. RESULTS AND DISCUSSION: The conjugate gradients method is shown to be optimal for solving problems of the kind considered. Convergence with experimental data is rapidly achieved with the appropriate model but not with alternative models. CONCLUSION: Lack of convergence using the conjugate gradients method can be taken to indicate inconsistency between the receptor binding model and the experimental data. Thus, the conjugate gradients method can be used to distinguish among receptor binding models.