ACE I/D Polymorphism in Hypertensive Patients of Kashmiri Population

BACKGROUND: The angiotensin-converting enzyme (ACE) gene in humans has an insertion-deletion (I/D) polymorphic state in intron 16 on chromosome 17q23. This polymorphism has been widely investigated in different diseases. In this study we aimed to investigate the ACE I/D genotype frequency in hyperte...

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Autores principales: Sameer, A. Syed, Syeed, Nidda, Tak, Shahid A., Bashir, Samina, Nissar, Saniya, Siddiqi, Mushtaq A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358231/
https://www.ncbi.nlm.nih.gov/pubmed/28352369
http://dx.doi.org/10.4021/cr101e
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author Sameer, A. Syed
Syeed, Nidda
Tak, Shahid A.
Bashir, Samina
Nissar, Saniya
Siddiqi, Mushtaq A.
author_facet Sameer, A. Syed
Syeed, Nidda
Tak, Shahid A.
Bashir, Samina
Nissar, Saniya
Siddiqi, Mushtaq A.
author_sort Sameer, A. Syed
collection PubMed
description BACKGROUND: The angiotensin-converting enzyme (ACE) gene in humans has an insertion-deletion (I/D) polymorphic state in intron 16 on chromosome 17q23. This polymorphism has been widely investigated in different diseases. In this study we aimed to investigate the ACE I/D genotype frequency in hypertensive cases in Kashmiri population. MATERIALS AND METHODS: We designed a case control study, where 52 hypertensive cases were studied for ACE I/D polymorphism against 150 age/sex matched controls taken from general population. The polymorphisms of ACE gene were investigated using polymerase chain reaction for detection of ACE I/D genotype. Fisher’s Chi square test was used for calculation of P value and OR. RESULTS: We found the frequency of ACE DD genotype to be 46.15% (24/52), II 23.07% (12/52) and DI 30.77% (16/52) in 52 hypertensive cases. CONCLUSIONS: The ACE I/D genotype is positively associated with hypertension in our population.
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spelling pubmed-53582312017-03-28 ACE I/D Polymorphism in Hypertensive Patients of Kashmiri Population Sameer, A. Syed Syeed, Nidda Tak, Shahid A. Bashir, Samina Nissar, Saniya Siddiqi, Mushtaq A. Cardiol Res Original Article BACKGROUND: The angiotensin-converting enzyme (ACE) gene in humans has an insertion-deletion (I/D) polymorphic state in intron 16 on chromosome 17q23. This polymorphism has been widely investigated in different diseases. In this study we aimed to investigate the ACE I/D genotype frequency in hypertensive cases in Kashmiri population. MATERIALS AND METHODS: We designed a case control study, where 52 hypertensive cases were studied for ACE I/D polymorphism against 150 age/sex matched controls taken from general population. The polymorphisms of ACE gene were investigated using polymerase chain reaction for detection of ACE I/D genotype. Fisher’s Chi square test was used for calculation of P value and OR. RESULTS: We found the frequency of ACE DD genotype to be 46.15% (24/52), II 23.07% (12/52) and DI 30.77% (16/52) in 52 hypertensive cases. CONCLUSIONS: The ACE I/D genotype is positively associated with hypertension in our population. Elmer Press 2010-12 2010-11-20 /pmc/articles/PMC5358231/ /pubmed/28352369 http://dx.doi.org/10.4021/cr101e Text en Copyright 2010, Sameer et al. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Sameer, A. Syed
Syeed, Nidda
Tak, Shahid A.
Bashir, Samina
Nissar, Saniya
Siddiqi, Mushtaq A.
ACE I/D Polymorphism in Hypertensive Patients of Kashmiri Population
title ACE I/D Polymorphism in Hypertensive Patients of Kashmiri Population
title_full ACE I/D Polymorphism in Hypertensive Patients of Kashmiri Population
title_fullStr ACE I/D Polymorphism in Hypertensive Patients of Kashmiri Population
title_full_unstemmed ACE I/D Polymorphism in Hypertensive Patients of Kashmiri Population
title_short ACE I/D Polymorphism in Hypertensive Patients of Kashmiri Population
title_sort ace i/d polymorphism in hypertensive patients of kashmiri population
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358231/
https://www.ncbi.nlm.nih.gov/pubmed/28352369
http://dx.doi.org/10.4021/cr101e
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