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Congenital Thrombophilia and Intracardiac Thrombosis: Probably an Underdiagnosed Event

BACKGROUND: To investigate the number of patients with congenital thrombophilia who presented an intracardiac thrombosis. METHODS: Personal files were reevaluated together with a time-unlimited search of the literature. RESULTS: Twenty-five patients with intracardiac thrombosis and congenital thromb...

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Autores principales: Girolami, Antonio, de Marinis, Giulia Berti, Treleani, Martina, Tasinato, Valentina, Girolami, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358248/
https://www.ncbi.nlm.nih.gov/pubmed/28352430
http://dx.doi.org/10.4021/cr278e
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author Girolami, Antonio
de Marinis, Giulia Berti
Treleani, Martina
Tasinato, Valentina
Girolami, Bruno
author_facet Girolami, Antonio
de Marinis, Giulia Berti
Treleani, Martina
Tasinato, Valentina
Girolami, Bruno
author_sort Girolami, Antonio
collection PubMed
description BACKGROUND: To investigate the number of patients with congenital thrombophilia who presented an intracardiac thrombosis. METHODS: Personal files were reevaluated together with a time-unlimited search of the literature. RESULTS: Twenty-five patients with intracardiac thrombosis and congenital thrombophilia have been gathered from the literature including the two personal cases. The distribution observed in thrombophilia patients is similar for left side or right side heart (9 vs 11 cases). The left ventricle and the right ventricle were involved in six or five instances, respectively. In one case, both ventricles were involved. On the contrary, the left atrium was involved in three cases whereas the right atrium was affected in six cases. In the remaining cases, more than one heart chamber was involved. CONCLUSIONS: In “normal” subjects, left side thromboses are predominant once catheter-associated thrombi are excluded. The reason of this discrepancy lies in the greater prothrombotic effect exercised by congenital thrombophilia on venous thrombosis compared to arterial thrombosis. The relative high prevalence of cardiac thrombosis seen in patients with antithrombin and protein C deficiencies indicated that a cardiac evaluation should be carried out in all patients with these two defects.
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spelling pubmed-53582482017-03-28 Congenital Thrombophilia and Intracardiac Thrombosis: Probably an Underdiagnosed Event Girolami, Antonio de Marinis, Giulia Berti Treleani, Martina Tasinato, Valentina Girolami, Bruno Cardiol Res Original Article BACKGROUND: To investigate the number of patients with congenital thrombophilia who presented an intracardiac thrombosis. METHODS: Personal files were reevaluated together with a time-unlimited search of the literature. RESULTS: Twenty-five patients with intracardiac thrombosis and congenital thrombophilia have been gathered from the literature including the two personal cases. The distribution observed in thrombophilia patients is similar for left side or right side heart (9 vs 11 cases). The left ventricle and the right ventricle were involved in six or five instances, respectively. In one case, both ventricles were involved. On the contrary, the left atrium was involved in three cases whereas the right atrium was affected in six cases. In the remaining cases, more than one heart chamber was involved. CONCLUSIONS: In “normal” subjects, left side thromboses are predominant once catheter-associated thrombi are excluded. The reason of this discrepancy lies in the greater prothrombotic effect exercised by congenital thrombophilia on venous thrombosis compared to arterial thrombosis. The relative high prevalence of cardiac thrombosis seen in patients with antithrombin and protein C deficiencies indicated that a cardiac evaluation should be carried out in all patients with these two defects. Elmer Press 2013-06 2013-07-11 /pmc/articles/PMC5358248/ /pubmed/28352430 http://dx.doi.org/10.4021/cr278e Text en Copyright 2013, Girolami et al. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Girolami, Antonio
de Marinis, Giulia Berti
Treleani, Martina
Tasinato, Valentina
Girolami, Bruno
Congenital Thrombophilia and Intracardiac Thrombosis: Probably an Underdiagnosed Event
title Congenital Thrombophilia and Intracardiac Thrombosis: Probably an Underdiagnosed Event
title_full Congenital Thrombophilia and Intracardiac Thrombosis: Probably an Underdiagnosed Event
title_fullStr Congenital Thrombophilia and Intracardiac Thrombosis: Probably an Underdiagnosed Event
title_full_unstemmed Congenital Thrombophilia and Intracardiac Thrombosis: Probably an Underdiagnosed Event
title_short Congenital Thrombophilia and Intracardiac Thrombosis: Probably an Underdiagnosed Event
title_sort congenital thrombophilia and intracardiac thrombosis: probably an underdiagnosed event
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358248/
https://www.ncbi.nlm.nih.gov/pubmed/28352430
http://dx.doi.org/10.4021/cr278e
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