Cargando…
Asymptomatic Left Bundle Branch Block Predicts New-Onset Congestive Heart Failure and Death From Cardiovascular Diseases
BACKGROUND: Left bundle branch block (LBBB) has been proposed as a risk factor for cardiovascular morbidity and mortality. We sought to characterize the strength of these associations in a population without preexisting clinical heart disease. METHODS: The association between LBBB and new-onset cong...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elmer Press
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358299/ https://www.ncbi.nlm.nih.gov/pubmed/28352414 http://dx.doi.org/10.4021/cr214w |
_version_ | 1782516210359861248 |
---|---|
author | Azadani, Peyman N. Soleimanirahbar, Ata Marcus, Gregory M. Haight, Thaddeus J. Hollenberg, Milton Olgin, Jeffrey E. Lee, Byron K. |
author_facet | Azadani, Peyman N. Soleimanirahbar, Ata Marcus, Gregory M. Haight, Thaddeus J. Hollenberg, Milton Olgin, Jeffrey E. Lee, Byron K. |
author_sort | Azadani, Peyman N. |
collection | PubMed |
description | BACKGROUND: Left bundle branch block (LBBB) has been proposed as a risk factor for cardiovascular morbidity and mortality. We sought to characterize the strength of these associations in a population without preexisting clinical heart disease. METHODS: The association between LBBB and new-onset congestive heart failure (CHF) or death from cardiovascular diseases was examined in 1,688 participants enrolled in the SPPARCS study who were free of known CHF or previous myocardial infarction. SPPARCS is a community-based cohort study in residents of Sonoma, California that are > 55 years. Medical history and 12-lead ECGs were obtained every 2 years for up to 6 years of follow-up. LBBB at enrollment or year 2 was considered “baseline” and assessed as a predictor of CHF and cardiovascular death ascertained at years 4 and 6. RESULTS: The prevalence of LBBB at baseline was 2.5% (n = 42). During 6 years of follow-up, 70 (4.8%) people developed new CHF. Incidence of CHF was higher in patients with LBBB than in participants without LBBB. This association persisted after controlling for potential confounders (odds ratio (OR): 2.85; 95% confidence interval (CI): 1.01 - 8.02; P = 0.047). A higher mortality from cardiovascular diseases was also found in participants with LBBB after adjusting for potential confounders (OR: 2.35, 95%CI: 1.02 - 5.41; P = 0.044). CONCLUSIONS: LBBB in the absence of a clinically detectable heart disease is associated with new-onset CHF and death from cardiovascular diseases. Further study is warranted to determine if additional diagnostic testing or earlier treatment in patients with asymptomatic LBBB can decrease cardiovascular morbidity or mortality. |
format | Online Article Text |
id | pubmed-5358299 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Elmer Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-53582992017-03-28 Asymptomatic Left Bundle Branch Block Predicts New-Onset Congestive Heart Failure and Death From Cardiovascular Diseases Azadani, Peyman N. Soleimanirahbar, Ata Marcus, Gregory M. Haight, Thaddeus J. Hollenberg, Milton Olgin, Jeffrey E. Lee, Byron K. Cardiol Res Original Article BACKGROUND: Left bundle branch block (LBBB) has been proposed as a risk factor for cardiovascular morbidity and mortality. We sought to characterize the strength of these associations in a population without preexisting clinical heart disease. METHODS: The association between LBBB and new-onset congestive heart failure (CHF) or death from cardiovascular diseases was examined in 1,688 participants enrolled in the SPPARCS study who were free of known CHF or previous myocardial infarction. SPPARCS is a community-based cohort study in residents of Sonoma, California that are > 55 years. Medical history and 12-lead ECGs were obtained every 2 years for up to 6 years of follow-up. LBBB at enrollment or year 2 was considered “baseline” and assessed as a predictor of CHF and cardiovascular death ascertained at years 4 and 6. RESULTS: The prevalence of LBBB at baseline was 2.5% (n = 42). During 6 years of follow-up, 70 (4.8%) people developed new CHF. Incidence of CHF was higher in patients with LBBB than in participants without LBBB. This association persisted after controlling for potential confounders (odds ratio (OR): 2.85; 95% confidence interval (CI): 1.01 - 8.02; P = 0.047). A higher mortality from cardiovascular diseases was also found in participants with LBBB after adjusting for potential confounders (OR: 2.35, 95%CI: 1.02 - 5.41; P = 0.044). CONCLUSIONS: LBBB in the absence of a clinically detectable heart disease is associated with new-onset CHF and death from cardiovascular diseases. Further study is warranted to determine if additional diagnostic testing or earlier treatment in patients with asymptomatic LBBB can decrease cardiovascular morbidity or mortality. Elmer Press 2012-12 2012-11-20 /pmc/articles/PMC5358299/ /pubmed/28352414 http://dx.doi.org/10.4021/cr214w Text en Copyright 2012, Azadani et al. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Azadani, Peyman N. Soleimanirahbar, Ata Marcus, Gregory M. Haight, Thaddeus J. Hollenberg, Milton Olgin, Jeffrey E. Lee, Byron K. Asymptomatic Left Bundle Branch Block Predicts New-Onset Congestive Heart Failure and Death From Cardiovascular Diseases |
title | Asymptomatic Left Bundle Branch Block Predicts New-Onset Congestive Heart Failure and Death From Cardiovascular Diseases |
title_full | Asymptomatic Left Bundle Branch Block Predicts New-Onset Congestive Heart Failure and Death From Cardiovascular Diseases |
title_fullStr | Asymptomatic Left Bundle Branch Block Predicts New-Onset Congestive Heart Failure and Death From Cardiovascular Diseases |
title_full_unstemmed | Asymptomatic Left Bundle Branch Block Predicts New-Onset Congestive Heart Failure and Death From Cardiovascular Diseases |
title_short | Asymptomatic Left Bundle Branch Block Predicts New-Onset Congestive Heart Failure and Death From Cardiovascular Diseases |
title_sort | asymptomatic left bundle branch block predicts new-onset congestive heart failure and death from cardiovascular diseases |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358299/ https://www.ncbi.nlm.nih.gov/pubmed/28352414 http://dx.doi.org/10.4021/cr214w |
work_keys_str_mv | AT azadanipeymann asymptomaticleftbundlebranchblockpredictsnewonsetcongestiveheartfailureanddeathfromcardiovasculardiseases AT soleimanirahbarata asymptomaticleftbundlebranchblockpredictsnewonsetcongestiveheartfailureanddeathfromcardiovasculardiseases AT marcusgregorym asymptomaticleftbundlebranchblockpredictsnewonsetcongestiveheartfailureanddeathfromcardiovasculardiseases AT haightthaddeusj asymptomaticleftbundlebranchblockpredictsnewonsetcongestiveheartfailureanddeathfromcardiovasculardiseases AT hollenbergmilton asymptomaticleftbundlebranchblockpredictsnewonsetcongestiveheartfailureanddeathfromcardiovasculardiseases AT olginjeffreye asymptomaticleftbundlebranchblockpredictsnewonsetcongestiveheartfailureanddeathfromcardiovasculardiseases AT leebyronk asymptomaticleftbundlebranchblockpredictsnewonsetcongestiveheartfailureanddeathfromcardiovasculardiseases |