Transposon insertional mutagenesis in mice identifies human breast cancer susceptibility genes and signatures for stratification

Robust prognostic gene signatures and therapeutic targets are difficult to derive from expression profiling because of the significant heterogeneity within breast cancer (BC) subtypes. Here, we performed forward genetic screening in mice using Sleeping Beauty transposon mutagenesis to identify candi...

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Detalles Bibliográficos
Autores principales: Chen, Liming, Jenjaroenpun, Piroon, Pillai, Andrea Mun Ching, Ivshina, Anna V., Ow, Ghim Siong, Efthimios, Motakis, Zhiqun, Tang, Tan, Tuan Zea, Lee, Song-Choon, Rogers, Keith, Ward, Jerrold M., Mori, Seiichi, Adams, David J., Jenkins, Nancy A., Copeland, Neal G., Ban, Kenneth Hon-Kim, Kuznetsov, Vladimir A., Thiery, Jean Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2017
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358385/
https://www.ncbi.nlm.nih.gov/pubmed/28251929
http://dx.doi.org/10.1073/pnas.1701512114

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