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Selection of DNA aptamers with two modified bases

The nucleobases comprising DNA and RNA aptamers provide considerably less chemical diversity than protein-based ligands, limiting their versatility. The introduction of novel functional groups at just one of the four bases in modified aptamers has recently led to dramatic improvement in the success...

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Detalles Bibliográficos
Autores principales:	Gawande, Bharat N., Rohloff, John C., Carter, Jeffrey D., von Carlowitz, Ira, Zhang, Chi, Schneider, Daniel J., Janjic, Nebojsa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2017
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358403/ https://www.ncbi.nlm.nih.gov/pubmed/28265062 http://dx.doi.org/10.1073/pnas.1615475114

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