Knockout of Vasohibin-1 Gene in Mice Results in Healthy Longevity with Reduced Expression of Insulin Receptor, Insulin Receptor Substrate 1, and Insulin Receptor Substrate 2 in Their White Adipose Tissue

Vasohibin-1 (Vash1), originally isolated as an endothelium-derived angiogenesis inhibitor, has a characteristic of promoting stress tolerance in endothelial cells (ECs). We therefore speculated that the lack of the vash1 gene would result in a short lifespan. However, to our surprise, vash1(−/−) mic...

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Detalles Bibliográficos
Autores principales: Takeda, Eichi, Suzuki, Yasuhiro, Yamada, Tetsuya, Katagiri, Hideki, Sato, Yasufumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358453/
https://www.ncbi.nlm.nih.gov/pubmed/28367331
http://dx.doi.org/10.1155/2017/9851380

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