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Differential S1P Receptor Profiles on M1- and M2-Polarized Macrophages Affect Macrophage Cytokine Production and Migration

Introduction. Macrophages are key players in complex biological processes. In response to environmental signals, macrophages undergo polarization towards a proinflammatory (M1) or anti-inflammatory (M2) phenotype. Sphingosine 1-phosphate (S1P) is a bioactive lysophospholipid that acts via 5 G-protei...

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Detalles Bibliográficos
Autores principales: Müller, Jan, von Bernstorff, Wolfram, Heidecke, Claus-Dieter, Schulze, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358463/
https://www.ncbi.nlm.nih.gov/pubmed/28367448
http://dx.doi.org/10.1155/2017/7584621