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Factors Predicting Renal Function Outcome after Augmentation Cystoplasty
We determined the cause of renal deterioration after augmentation cystoplasty (AC). Twenty-nine adult patients with refractory bladder dysfunction and who underwent ileocystoplasty from 2004 to 2015 were studied. Patients with a decline in glomerular filtration rate (GFR) after augmentation were rev...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358470/ https://www.ncbi.nlm.nih.gov/pubmed/28367330 http://dx.doi.org/10.1155/2017/3929352 |
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author | Mehmood, Shahbaz Seyam, Raouf Firdous, Sadia Altaweel, Waleed Mohammad |
author_facet | Mehmood, Shahbaz Seyam, Raouf Firdous, Sadia Altaweel, Waleed Mohammad |
author_sort | Mehmood, Shahbaz |
collection | PubMed |
description | We determined the cause of renal deterioration after augmentation cystoplasty (AC). Twenty-nine adult patients with refractory bladder dysfunction and who underwent ileocystoplasty from 2004 to 2015 were studied. Patients with a decline in glomerular filtration rate (GFR) after augmentation were reviewed. The primary outcome was to determine the factors that might lead to deterioration of estimated GFR. Median follow-up was 7.0 ± 2.6 years. Significant bladder capacity, end filling pressure, and bladder compliance were achieved from median 114 ± 53.6 to 342.1 ± 68.3 ml (p = .0001), 68.5 ± 19.9 to 28.2 ± 6.9 cm H(2)O (p = .0001), and 3.0 ± 2.1 to 12.8 ± 3.9 (p = .0001), respectively. Renal function remained stable and improved in 22 (76%) patients from median eGFR 135 ± 81.98 to 142.82 ± 94.4 ml/min/1.73 m(2) (p = .160). Significant deterioration was found in 7 (24%) patients from median eGFR 68.25 ± 42 to 36.57 ± 35.33 (p = .001). The causes of renal deterioration were noncompliance to self-catheterization (2 patients), posterior urethral valve/dysplastic kidneys (2 patients), and reflux/infection (2 patients). On multivariate analysis, recurrent pyelonephritis (OR 3.87, p = 0.0155) and noncompliance (OR 30.78, p = 0.0156) were significant. We concluded that AC is not the cause of progression to end-stage renal disease in patients with renal insufficiency. |
format | Online Article Text |
id | pubmed-5358470 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-53584702017-04-02 Factors Predicting Renal Function Outcome after Augmentation Cystoplasty Mehmood, Shahbaz Seyam, Raouf Firdous, Sadia Altaweel, Waleed Mohammad Int J Nephrol Research Article We determined the cause of renal deterioration after augmentation cystoplasty (AC). Twenty-nine adult patients with refractory bladder dysfunction and who underwent ileocystoplasty from 2004 to 2015 were studied. Patients with a decline in glomerular filtration rate (GFR) after augmentation were reviewed. The primary outcome was to determine the factors that might lead to deterioration of estimated GFR. Median follow-up was 7.0 ± 2.6 years. Significant bladder capacity, end filling pressure, and bladder compliance were achieved from median 114 ± 53.6 to 342.1 ± 68.3 ml (p = .0001), 68.5 ± 19.9 to 28.2 ± 6.9 cm H(2)O (p = .0001), and 3.0 ± 2.1 to 12.8 ± 3.9 (p = .0001), respectively. Renal function remained stable and improved in 22 (76%) patients from median eGFR 135 ± 81.98 to 142.82 ± 94.4 ml/min/1.73 m(2) (p = .160). Significant deterioration was found in 7 (24%) patients from median eGFR 68.25 ± 42 to 36.57 ± 35.33 (p = .001). The causes of renal deterioration were noncompliance to self-catheterization (2 patients), posterior urethral valve/dysplastic kidneys (2 patients), and reflux/infection (2 patients). On multivariate analysis, recurrent pyelonephritis (OR 3.87, p = 0.0155) and noncompliance (OR 30.78, p = 0.0156) were significant. We concluded that AC is not the cause of progression to end-stage renal disease in patients with renal insufficiency. Hindawi 2017 2017-03-06 /pmc/articles/PMC5358470/ /pubmed/28367330 http://dx.doi.org/10.1155/2017/3929352 Text en Copyright © 2017 Shahbaz Mehmood et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Mehmood, Shahbaz Seyam, Raouf Firdous, Sadia Altaweel, Waleed Mohammad Factors Predicting Renal Function Outcome after Augmentation Cystoplasty |
title | Factors Predicting Renal Function Outcome after Augmentation Cystoplasty |
title_full | Factors Predicting Renal Function Outcome after Augmentation Cystoplasty |
title_fullStr | Factors Predicting Renal Function Outcome after Augmentation Cystoplasty |
title_full_unstemmed | Factors Predicting Renal Function Outcome after Augmentation Cystoplasty |
title_short | Factors Predicting Renal Function Outcome after Augmentation Cystoplasty |
title_sort | factors predicting renal function outcome after augmentation cystoplasty |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358470/ https://www.ncbi.nlm.nih.gov/pubmed/28367330 http://dx.doi.org/10.1155/2017/3929352 |
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