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Factors Predicting Renal Function Outcome after Augmentation Cystoplasty

We determined the cause of renal deterioration after augmentation cystoplasty (AC). Twenty-nine adult patients with refractory bladder dysfunction and who underwent ileocystoplasty from 2004 to 2015 were studied. Patients with a decline in glomerular filtration rate (GFR) after augmentation were rev...

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Autores principales: Mehmood, Shahbaz, Seyam, Raouf, Firdous, Sadia, Altaweel, Waleed Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358470/
https://www.ncbi.nlm.nih.gov/pubmed/28367330
http://dx.doi.org/10.1155/2017/3929352
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author Mehmood, Shahbaz
Seyam, Raouf
Firdous, Sadia
Altaweel, Waleed Mohammad
author_facet Mehmood, Shahbaz
Seyam, Raouf
Firdous, Sadia
Altaweel, Waleed Mohammad
author_sort Mehmood, Shahbaz
collection PubMed
description We determined the cause of renal deterioration after augmentation cystoplasty (AC). Twenty-nine adult patients with refractory bladder dysfunction and who underwent ileocystoplasty from 2004 to 2015 were studied. Patients with a decline in glomerular filtration rate (GFR) after augmentation were reviewed. The primary outcome was to determine the factors that might lead to deterioration of estimated GFR. Median follow-up was 7.0 ± 2.6 years. Significant bladder capacity, end filling pressure, and bladder compliance were achieved from median 114 ± 53.6 to 342.1 ± 68.3 ml (p = .0001), 68.5 ± 19.9 to 28.2 ± 6.9 cm H(2)O (p = .0001), and 3.0 ± 2.1 to 12.8 ± 3.9 (p = .0001), respectively. Renal function remained stable and improved in 22 (76%) patients from median eGFR 135 ± 81.98 to 142.82 ± 94.4 ml/min/1.73 m(2) (p = .160). Significant deterioration was found in 7 (24%) patients from median eGFR 68.25 ± 42 to 36.57 ± 35.33 (p = .001). The causes of renal deterioration were noncompliance to self-catheterization (2 patients), posterior urethral valve/dysplastic kidneys (2 patients), and reflux/infection (2 patients). On multivariate analysis, recurrent pyelonephritis (OR 3.87, p = 0.0155) and noncompliance (OR 30.78, p = 0.0156) were significant. We concluded that AC is not the cause of progression to end-stage renal disease in patients with renal insufficiency.
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spelling pubmed-53584702017-04-02 Factors Predicting Renal Function Outcome after Augmentation Cystoplasty Mehmood, Shahbaz Seyam, Raouf Firdous, Sadia Altaweel, Waleed Mohammad Int J Nephrol Research Article We determined the cause of renal deterioration after augmentation cystoplasty (AC). Twenty-nine adult patients with refractory bladder dysfunction and who underwent ileocystoplasty from 2004 to 2015 were studied. Patients with a decline in glomerular filtration rate (GFR) after augmentation were reviewed. The primary outcome was to determine the factors that might lead to deterioration of estimated GFR. Median follow-up was 7.0 ± 2.6 years. Significant bladder capacity, end filling pressure, and bladder compliance were achieved from median 114 ± 53.6 to 342.1 ± 68.3 ml (p = .0001), 68.5 ± 19.9 to 28.2 ± 6.9 cm H(2)O (p = .0001), and 3.0 ± 2.1 to 12.8 ± 3.9 (p = .0001), respectively. Renal function remained stable and improved in 22 (76%) patients from median eGFR 135 ± 81.98 to 142.82 ± 94.4 ml/min/1.73 m(2) (p = .160). Significant deterioration was found in 7 (24%) patients from median eGFR 68.25 ± 42 to 36.57 ± 35.33 (p = .001). The causes of renal deterioration were noncompliance to self-catheterization (2 patients), posterior urethral valve/dysplastic kidneys (2 patients), and reflux/infection (2 patients). On multivariate analysis, recurrent pyelonephritis (OR 3.87, p = 0.0155) and noncompliance (OR 30.78, p = 0.0156) were significant. We concluded that AC is not the cause of progression to end-stage renal disease in patients with renal insufficiency. Hindawi 2017 2017-03-06 /pmc/articles/PMC5358470/ /pubmed/28367330 http://dx.doi.org/10.1155/2017/3929352 Text en Copyright © 2017 Shahbaz Mehmood et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Mehmood, Shahbaz
Seyam, Raouf
Firdous, Sadia
Altaweel, Waleed Mohammad
Factors Predicting Renal Function Outcome after Augmentation Cystoplasty
title Factors Predicting Renal Function Outcome after Augmentation Cystoplasty
title_full Factors Predicting Renal Function Outcome after Augmentation Cystoplasty
title_fullStr Factors Predicting Renal Function Outcome after Augmentation Cystoplasty
title_full_unstemmed Factors Predicting Renal Function Outcome after Augmentation Cystoplasty
title_short Factors Predicting Renal Function Outcome after Augmentation Cystoplasty
title_sort factors predicting renal function outcome after augmentation cystoplasty
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358470/
https://www.ncbi.nlm.nih.gov/pubmed/28367330
http://dx.doi.org/10.1155/2017/3929352
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