CCL2 and CCR2 regulate pain-related behaviour and early gene expression in post-traumatic murine osteoarthritis but contribute little to chondropathy

OBJECTIVE: The role of inflammation in structural and symptomatic osteoarthritis (OA) remains unclear. One key mediator of inflammation is the chemokine CCL2, primarily responsible for attracting monocytes to sites of injury. We investigated the role of CCL2 and its receptor CCR2 in experimental OA....

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Detalles Bibliográficos
Autores principales: Miotla Zarebska, J., Chanalaris, A., Driscoll, C., Burleigh, A., Miller, R.E., Malfait, A.M., Stott, B., Vincent, T.L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: W.B. Saunders For The Osteoarthritis Research Society 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358501/
https://www.ncbi.nlm.nih.gov/pubmed/27746376
http://dx.doi.org/10.1016/j.joca.2016.10.008

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