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The role of sphingolipid signalling in diabetes-associated pathologies (Review)
Sphingosine kinase (SphK) is an important signalling enzyme that catalyses the phosphorylation of sphingosine (Sph) to form sphingosine-1-phosphate (S1P). The multifunctional lipid, S1P binds to a family of five G protein-coupled receptors (GPCRs). As an intracellular second messenger, S1P activates...
Autores principales: | Ng, Mei Li, Wadham, Carol, Sukocheva, Olga A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358714/ https://www.ncbi.nlm.nih.gov/pubmed/28075451 http://dx.doi.org/10.3892/ijmm.2017.2855 |
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