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The role of sphingolipid signalling in diabetes-associated pathologies (Review)

Sphingosine kinase (SphK) is an important signalling enzyme that catalyses the phosphorylation of sphingosine (Sph) to form sphingosine-1-phosphate (S1P). The multifunctional lipid, S1P binds to a family of five G protein-coupled receptors (GPCRs). As an intracellular second messenger, S1P activates...

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Detalles Bibliográficos
Autores principales: Ng, Mei Li, Wadham, Carol, Sukocheva, Olga A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358714/
https://www.ncbi.nlm.nih.gov/pubmed/28075451
http://dx.doi.org/10.3892/ijmm.2017.2855

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