Conducting the finale of DNA replication

Anomalies in dismantling the machinery of DNA replication can compromise genome integrity and contribute to tumorigenesis and aging. In this issue of Genes & Development, Dewar and colleagues (pp. 275–290) identified an E3 ubiquitin ligase, CUL2(LRR2), that modifies a subunit of the replicative...

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Detalles Bibliográficos
Autores principales: Akopian, David, Rape, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Outlook
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358719/
https://www.ncbi.nlm.nih.gov/pubmed/28270514
http://dx.doi.org/10.1101/gad.297184.117
Descripción
Sumario:Anomalies in dismantling the machinery of DNA replication can compromise genome integrity and contribute to tumorigenesis and aging. In this issue of Genes & Development, Dewar and colleagues (pp. 275–290) identified an E3 ubiquitin ligase, CUL2(LRR2), that modifies a subunit of the replicative CMG (Cdc45, minichromosome maintenance [MCM] subunits 2–7, and the GINS complex) helicase and triggers disassembly of the replication machinery. Their study offers critical insight into the mechanism of DNA replication termination while at the same time raising important questions for future research.

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