Conducting the finale of DNA replication

Anomalies in dismantling the machinery of DNA replication can compromise genome integrity and contribute to tumorigenesis and aging. In this issue of Genes & Development, Dewar and colleagues (pp. 275–290) identified an E3 ubiquitin ligase, CUL2(LRR2), that modifies a subunit of the replicative...

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Detalles Bibliográficos
Autores principales: Akopian, David, Rape, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Outlook
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358719/
https://www.ncbi.nlm.nih.gov/pubmed/28270514
http://dx.doi.org/10.1101/gad.297184.117
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author Akopian, David
Rape, Michael
author_facet Akopian, David
Rape, Michael
author_sort Akopian, David
collection PubMed
description Anomalies in dismantling the machinery of DNA replication can compromise genome integrity and contribute to tumorigenesis and aging. In this issue of Genes & Development, Dewar and colleagues (pp. 275–290) identified an E3 ubiquitin ligase, CUL2(LRR2), that modifies a subunit of the replicative CMG (Cdc45, minichromosome maintenance [MCM] subunits 2–7, and the GINS complex) helicase and triggers disassembly of the replication machinery. Their study offers critical insight into the mechanism of DNA replication termination while at the same time raising important questions for future research.
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spelling pubmed-53587192017-08-01 Conducting the finale of DNA replication Akopian, David Rape, Michael Genes Dev Outlook Anomalies in dismantling the machinery of DNA replication can compromise genome integrity and contribute to tumorigenesis and aging. In this issue of Genes & Development, Dewar and colleagues (pp. 275–290) identified an E3 ubiquitin ligase, CUL2(LRR2), that modifies a subunit of the replicative CMG (Cdc45, minichromosome maintenance [MCM] subunits 2–7, and the GINS complex) helicase and triggers disassembly of the replication machinery. Their study offers critical insight into the mechanism of DNA replication termination while at the same time raising important questions for future research. Cold Spring Harbor Laboratory Press 2017-02-01 /pmc/articles/PMC5358719/ /pubmed/28270514 http://dx.doi.org/10.1101/gad.297184.117 Text en © 2017 Akopian and Rape; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Outlook
Akopian, David
Rape, Michael
Conducting the finale of DNA replication
title Conducting the finale of DNA replication
title_full Conducting the finale of DNA replication
title_fullStr Conducting the finale of DNA replication
title_full_unstemmed Conducting the finale of DNA replication
title_short Conducting the finale of DNA replication
title_sort conducting the finale of dna replication
topic Outlook
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358719/
https://www.ncbi.nlm.nih.gov/pubmed/28270514
http://dx.doi.org/10.1101/gad.297184.117
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