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The metabolic programming of stem cells
Advances in metabolomics have deepened our understanding of the roles that specific modes of metabolism play in programming stem cell fates. Here, we review recent metabolomic studies of stem cell metabolism that have revealed how metabolic pathways can convey changes in the extrinsic environment or...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory Press
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358754/ https://www.ncbi.nlm.nih.gov/pubmed/28314766 http://dx.doi.org/10.1101/gad.293167.116 |
| _version_ | 1782516274760253440 |
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| author | Shyh-Chang, Ng Ng, Huck-Hui |
| author_facet | Shyh-Chang, Ng Ng, Huck-Hui |
| author_sort | Shyh-Chang, Ng |
| collection | PubMed |
| description | Advances in metabolomics have deepened our understanding of the roles that specific modes of metabolism play in programming stem cell fates. Here, we review recent metabolomic studies of stem cell metabolism that have revealed how metabolic pathways can convey changes in the extrinsic environment or their niche to program stem cell fates. The metabolic programming of stem cells represents a fine balance between the intrinsic needs of a cellular state and the constraints imposed by extrinsic conditions. A more complete understanding of these needs and constraints will afford us greater mastery over our control of stem cell fates. |
| format | Online Article Text |
| id | pubmed-5358754 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2017 |
| publisher | Cold Spring Harbor Laboratory Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-53587542017-08-15 The metabolic programming of stem cells Shyh-Chang, Ng Ng, Huck-Hui Genes Dev Review Advances in metabolomics have deepened our understanding of the roles that specific modes of metabolism play in programming stem cell fates. Here, we review recent metabolomic studies of stem cell metabolism that have revealed how metabolic pathways can convey changes in the extrinsic environment or their niche to program stem cell fates. The metabolic programming of stem cells represents a fine balance between the intrinsic needs of a cellular state and the constraints imposed by extrinsic conditions. A more complete understanding of these needs and constraints will afford us greater mastery over our control of stem cell fates. Cold Spring Harbor Laboratory Press 2017-02-15 /pmc/articles/PMC5358754/ /pubmed/28314766 http://dx.doi.org/10.1101/gad.293167.116 Text en © 2017 Shyh-Chang and Ng; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. |
| spellingShingle | Review Shyh-Chang, Ng Ng, Huck-Hui The metabolic programming of stem cells |
| title | The metabolic programming of stem cells |
| title_full | The metabolic programming of stem cells |
| title_fullStr | The metabolic programming of stem cells |
| title_full_unstemmed | The metabolic programming of stem cells |
| title_short | The metabolic programming of stem cells |
| title_sort | metabolic programming of stem cells |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358754/ https://www.ncbi.nlm.nih.gov/pubmed/28314766 http://dx.doi.org/10.1101/gad.293167.116 |
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