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A prosurvival DNA damage-induced cytoplasmic interferon response is mediated by end resection factors and is limited by Trex1

Radiotherapy and chemotherapy are effective treatment methods for many types of cancer, but resistance is common. Recent findings indicate that antiviral type I interferon (IFN) signaling is induced by these treatments. However, the underlying mechanisms still need to be elucidated. Expression of a...

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Detalles Bibliográficos
Autores principales: Erdal, Erkin, Haider, Syed, Rehwinkel, Jan, Harris, Adrian L., McHugh, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358756/
https://www.ncbi.nlm.nih.gov/pubmed/28279982
http://dx.doi.org/10.1101/gad.289769.116