Lung function parameters improve prediction of VO(2peak) in an elderly population: The Generation 100 study

Peak oxygen uptake (VO(2peak)) is an indicator of cardiovascular health and a useful tool for risk stratification. Direct measurement of VO(2peak) is resource-demanding and may be contraindicated. There exist several non-exercise models to estimate VO(2peak) that utilize easily obtainable health parameters, but none of them includes lung function measures or hemoglobin concentrations. We aimed to test whether addition of these parameters could improve prediction of VO(2peak) compared to an established model that includes age, waist circumference, self-reported physical activity and resting heart rate. We included 1431 subjects aged 69-77 years that completed a laboratory test of VO(2peak), spirometry, and a gas diffusion test. Prediction models for VO(2peak) were developed with multiple linear regression, and goodness of fit was evaluated. Forced expiratory volume in one second (FEV(1)), diffusing capacity of the lung for carbon monoxide and blood hemoglobin concentration significantly improved the ability of the established model to predict VO(2peak). The explained variance of the model increased from 31% to 48% for men and from 32% to 38% for women (p<0.001). FEV(1), diffusing capacity of the lungs for carbon monoxide and hemoglobin concentration substantially improved the accuracy of VO(2peak) prediction when added to an established model in an elderly population.