Macrocyclized Extended Peptides: Inhibiting the Substrate-Recognition Domain of Tankyrase

[Image: see text] We report a double-click macrocyclization approach for the design of constrained peptide inhibitors having non-helical or extended conformations. Our targets are the tankyrase proteins (TNKS), poly(ADP-ribose) polymerases (PARP) that regulate Wnt signaling by targeting Axin for deg...

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Detalles Bibliográficos
Autores principales: Xu, Wenshu, Lau, Yu Heng, Fischer, Gerhard, Tan, Yaw Sing, Chattopadhyay, Anasuya, de la Roche, Marc, Hyvönen, Marko, Verma, Chandra, Spring, David R., Itzhaki, Laura S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358875/
https://www.ncbi.nlm.nih.gov/pubmed/28084734
http://dx.doi.org/10.1021/jacs.6b10234

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358875/
https://www.ncbi.nlm.nih.gov/pubmed/28084734
http://dx.doi.org/10.1021/jacs.6b10234

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