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Serelaxin Treatment Reduces Oxidative Stress and Increases Aldehyde Dehydrogenase-2 to Attenuate Nitrate Tolerance

Background: Glyceryl trinitrate (GTN) is a commonly prescribed treatment for acute heart failure patients. However, prolonged GTN treatment induces tolerance, largely due to increased oxidative stress and reduced aldehyde dehydrogenase-2 (ALDH-2) expression. Serelaxin has several vasoprotective prop...

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Detalles Bibliográficos
Autores principales:	Leo, Chen Huei, Fernando, Dhanushke T., Tran, Lillie, Ng, Hooi Hooi, Marshall, Sarah A., Parry, Laura J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359255/ https://www.ncbi.nlm.nih.gov/pubmed/28377719 http://dx.doi.org/10.3389/fphar.2017.00141

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