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Association between Parathyroid Hormone, 25 (OH) Vitamin D, and Chronic Kidney Disease: A Population-Based Study

Identification of the accurate risk factor for CKD remains mandatory to combat the high prevalence of diseases. Growing evidence suggests the association of serum vitamin D with diverse health conditions. However, the relationship between vitamin D, intact parathyroid hormone (PTH), and calcium-phos...

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Autores principales: Wang, Wei-Hao, Chen, Li-Wei, Lee, Chin-Chan, Sun, Chiao-Yin, Shyu, Yu-Chiau, Hsu, Heng-Rong, Chien, Rong-Nang, Wu, I-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359435/
https://www.ncbi.nlm.nih.gov/pubmed/28367447
http://dx.doi.org/10.1155/2017/7435657
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author Wang, Wei-Hao
Chen, Li-Wei
Lee, Chin-Chan
Sun, Chiao-Yin
Shyu, Yu-Chiau
Hsu, Heng-Rong
Chien, Rong-Nang
Wu, I-Wen
author_facet Wang, Wei-Hao
Chen, Li-Wei
Lee, Chin-Chan
Sun, Chiao-Yin
Shyu, Yu-Chiau
Hsu, Heng-Rong
Chien, Rong-Nang
Wu, I-Wen
author_sort Wang, Wei-Hao
collection PubMed
description Identification of the accurate risk factor for CKD remains mandatory to combat the high prevalence of diseases. Growing evidence suggests the association of serum vitamin D with diverse health conditions. However, the relationship between vitamin D, intact parathyroid hormone (PTH), and calcium-phosphate metabolism and development of CKD remains controversial. We conduct this cross-sectional observational study to investigate the association between serum 25 (OH) vitamin D, intact PTH, and calcium and phosphate levels with eGFR and albuminuria, as a surrogate marker of CKD, in a community population. A total of 4080 participants were recruited. The mean age was 58.4 ± 13.3 years and 1480 (36.3%) were men. The mean eGFR was 94.1 ± 26.3 mL/min/1.73 m(2). The prevalence of CKD was 19.8%. Serum 25 (OH) vitamin D and log intact PTH levels were inversely correlated with eGFR but positively correlated with log albuminuria. Logistic regression analysis identified the log intact PTH as an independent factor associated with eGFR ≤ 60 mL/min/1.73 m(2) and proteinuria. This association was consistent when serum intact PTH was analyzed as continuous as well as categorical variables (as hyperparathyroidism). The relationship remains significant using resampling subset analysis with comparable baseline characteristics and adjustment for 25 (OH) vitamin D, calcium, and phosphate levels. This finding warranted further research to clarify the causal relationship of PTH/25 (OH) vitamin D with the risk of CKD in the general population.
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spelling pubmed-53594352017-04-02 Association between Parathyroid Hormone, 25 (OH) Vitamin D, and Chronic Kidney Disease: A Population-Based Study Wang, Wei-Hao Chen, Li-Wei Lee, Chin-Chan Sun, Chiao-Yin Shyu, Yu-Chiau Hsu, Heng-Rong Chien, Rong-Nang Wu, I-Wen Biomed Res Int Research Article Identification of the accurate risk factor for CKD remains mandatory to combat the high prevalence of diseases. Growing evidence suggests the association of serum vitamin D with diverse health conditions. However, the relationship between vitamin D, intact parathyroid hormone (PTH), and calcium-phosphate metabolism and development of CKD remains controversial. We conduct this cross-sectional observational study to investigate the association between serum 25 (OH) vitamin D, intact PTH, and calcium and phosphate levels with eGFR and albuminuria, as a surrogate marker of CKD, in a community population. A total of 4080 participants were recruited. The mean age was 58.4 ± 13.3 years and 1480 (36.3%) were men. The mean eGFR was 94.1 ± 26.3 mL/min/1.73 m(2). The prevalence of CKD was 19.8%. Serum 25 (OH) vitamin D and log intact PTH levels were inversely correlated with eGFR but positively correlated with log albuminuria. Logistic regression analysis identified the log intact PTH as an independent factor associated with eGFR ≤ 60 mL/min/1.73 m(2) and proteinuria. This association was consistent when serum intact PTH was analyzed as continuous as well as categorical variables (as hyperparathyroidism). The relationship remains significant using resampling subset analysis with comparable baseline characteristics and adjustment for 25 (OH) vitamin D, calcium, and phosphate levels. This finding warranted further research to clarify the causal relationship of PTH/25 (OH) vitamin D with the risk of CKD in the general population. Hindawi 2017 2017-03-07 /pmc/articles/PMC5359435/ /pubmed/28367447 http://dx.doi.org/10.1155/2017/7435657 Text en Copyright © 2017 Wei-Hao Wang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wang, Wei-Hao
Chen, Li-Wei
Lee, Chin-Chan
Sun, Chiao-Yin
Shyu, Yu-Chiau
Hsu, Heng-Rong
Chien, Rong-Nang
Wu, I-Wen
Association between Parathyroid Hormone, 25 (OH) Vitamin D, and Chronic Kidney Disease: A Population-Based Study
title Association between Parathyroid Hormone, 25 (OH) Vitamin D, and Chronic Kidney Disease: A Population-Based Study
title_full Association between Parathyroid Hormone, 25 (OH) Vitamin D, and Chronic Kidney Disease: A Population-Based Study
title_fullStr Association between Parathyroid Hormone, 25 (OH) Vitamin D, and Chronic Kidney Disease: A Population-Based Study
title_full_unstemmed Association between Parathyroid Hormone, 25 (OH) Vitamin D, and Chronic Kidney Disease: A Population-Based Study
title_short Association between Parathyroid Hormone, 25 (OH) Vitamin D, and Chronic Kidney Disease: A Population-Based Study
title_sort association between parathyroid hormone, 25 (oh) vitamin d, and chronic kidney disease: a population-based study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359435/
https://www.ncbi.nlm.nih.gov/pubmed/28367447
http://dx.doi.org/10.1155/2017/7435657
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