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Lectins, Interconnecting Proteins with Biotechnological/Pharmacological and Therapeutic Applications

Lectins are proteins extensively used in biomedical applications with property to recognize carbohydrates through carbohydrate-binding sites, which identify glycans attached to cell surfaces, glycoconjugates, or free sugars, detecting abnormal cells and biomarkers related to diseases. These lectin a...

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Autores principales: Coelho, Luana Cassandra Breitenbach Barroso, Silva, Priscila Marcelino dos Santos, Lima, Vera Lúcia de Menezes, Pontual, Emmanuel Viana, Paiva, Patrícia Maria Guedes, Napoleão, Thiago Henrique, Correia, Maria Tereza dos Santos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359455/
https://www.ncbi.nlm.nih.gov/pubmed/28367220
http://dx.doi.org/10.1155/2017/1594074
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author Coelho, Luana Cassandra Breitenbach Barroso
Silva, Priscila Marcelino dos Santos
Lima, Vera Lúcia de Menezes
Pontual, Emmanuel Viana
Paiva, Patrícia Maria Guedes
Napoleão, Thiago Henrique
Correia, Maria Tereza dos Santos
author_facet Coelho, Luana Cassandra Breitenbach Barroso
Silva, Priscila Marcelino dos Santos
Lima, Vera Lúcia de Menezes
Pontual, Emmanuel Viana
Paiva, Patrícia Maria Guedes
Napoleão, Thiago Henrique
Correia, Maria Tereza dos Santos
author_sort Coelho, Luana Cassandra Breitenbach Barroso
collection PubMed
description Lectins are proteins extensively used in biomedical applications with property to recognize carbohydrates through carbohydrate-binding sites, which identify glycans attached to cell surfaces, glycoconjugates, or free sugars, detecting abnormal cells and biomarkers related to diseases. These lectin abilities promoted interesting results in experimental treatments of immunological diseases, wounds, and cancer. Lectins obtained from virus, microorganisms, algae, animals, and plants were reported as modulators and tool markers in vivo and in vitro; these molecules also play a role in the induction of mitosis and immune responses, contributing for resolution of infections and inflammations. Lectins revealed healing effect through induction of reepithelialization and cicatrization of wounds. Some lectins have been efficient agents against virus, fungi, bacteria, and helminths at low concentrations. Lectin-mediated bioadhesion has been an interesting characteristic for development of drug delivery systems. Lectin histochemistry and lectin-based biosensors are useful to detect transformed tissues and biomarkers related to disease occurrence; antitumor lectins reported are promising for cancer therapy. Here, we address lectins from distinct sources with some biological effect and biotechnological potential in the diagnosis and therapeutic of diseases, highlighting many advances in this growing field.
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spelling pubmed-53594552017-04-02 Lectins, Interconnecting Proteins with Biotechnological/Pharmacological and Therapeutic Applications Coelho, Luana Cassandra Breitenbach Barroso Silva, Priscila Marcelino dos Santos Lima, Vera Lúcia de Menezes Pontual, Emmanuel Viana Paiva, Patrícia Maria Guedes Napoleão, Thiago Henrique Correia, Maria Tereza dos Santos Evid Based Complement Alternat Med Review Article Lectins are proteins extensively used in biomedical applications with property to recognize carbohydrates through carbohydrate-binding sites, which identify glycans attached to cell surfaces, glycoconjugates, or free sugars, detecting abnormal cells and biomarkers related to diseases. These lectin abilities promoted interesting results in experimental treatments of immunological diseases, wounds, and cancer. Lectins obtained from virus, microorganisms, algae, animals, and plants were reported as modulators and tool markers in vivo and in vitro; these molecules also play a role in the induction of mitosis and immune responses, contributing for resolution of infections and inflammations. Lectins revealed healing effect through induction of reepithelialization and cicatrization of wounds. Some lectins have been efficient agents against virus, fungi, bacteria, and helminths at low concentrations. Lectin-mediated bioadhesion has been an interesting characteristic for development of drug delivery systems. Lectin histochemistry and lectin-based biosensors are useful to detect transformed tissues and biomarkers related to disease occurrence; antitumor lectins reported are promising for cancer therapy. Here, we address lectins from distinct sources with some biological effect and biotechnological potential in the diagnosis and therapeutic of diseases, highlighting many advances in this growing field. Hindawi 2017 2017-03-07 /pmc/articles/PMC5359455/ /pubmed/28367220 http://dx.doi.org/10.1155/2017/1594074 Text en Copyright © 2017 Luana Cassandra Breitenbach Barroso Coelho et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Coelho, Luana Cassandra Breitenbach Barroso
Silva, Priscila Marcelino dos Santos
Lima, Vera Lúcia de Menezes
Pontual, Emmanuel Viana
Paiva, Patrícia Maria Guedes
Napoleão, Thiago Henrique
Correia, Maria Tereza dos Santos
Lectins, Interconnecting Proteins with Biotechnological/Pharmacological and Therapeutic Applications
title Lectins, Interconnecting Proteins with Biotechnological/Pharmacological and Therapeutic Applications
title_full Lectins, Interconnecting Proteins with Biotechnological/Pharmacological and Therapeutic Applications
title_fullStr Lectins, Interconnecting Proteins with Biotechnological/Pharmacological and Therapeutic Applications
title_full_unstemmed Lectins, Interconnecting Proteins with Biotechnological/Pharmacological and Therapeutic Applications
title_short Lectins, Interconnecting Proteins with Biotechnological/Pharmacological and Therapeutic Applications
title_sort lectins, interconnecting proteins with biotechnological/pharmacological and therapeutic applications
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359455/
https://www.ncbi.nlm.nih.gov/pubmed/28367220
http://dx.doi.org/10.1155/2017/1594074
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