Mechanistic and structural basis of bioengineered bovine Cathelicidin-5 with optimized therapeutic activity

Peptide-drug discovery using host-defense peptides becomes promising against antibiotic-resistant pathogens and cancer cells. Here, we customized the therapeutic activity of bovine cathelicidin-5 targeting to bacteria, protozoa, and tumor cells. The membrane dependent conformational adaptability and...

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Detalles Bibliográficos
Autores principales: Sahoo, Bikash R., Maruyama, Kenta, Edula, Jyotheeswara R., Tougan, Takahiro, Lin, Yuxi, Lee, Young-Ho, Horii, Toshihiro, Fujiwara, Toshimichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359555/
https://www.ncbi.nlm.nih.gov/pubmed/28322271
http://dx.doi.org/10.1038/srep44781

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359555/
https://www.ncbi.nlm.nih.gov/pubmed/28322271
http://dx.doi.org/10.1038/srep44781

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