Signalling mechanisms mediating Zn(2+)-induced TRPM2 channel activation and cell death in microglial cells

Excessive Zn(2+) causes brain damage via promoting ROS generation. Here we investigated the role of ROS-sensitive TRPM2 channel in H(2)O(2)/Zn(2+)-induced Ca(2+) signalling and cell death in microglial cells. H(2)O(2)/Zn(2+) induced concentration-dependent increases in cytosolic Ca(2+) concentration...

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Detalles Bibliográficos
Autores principales: Mortadza, Sharifah Syed, Sim, Joan A., Stacey, Martin, Jiang, Lin-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359577/
https://www.ncbi.nlm.nih.gov/pubmed/28322340
http://dx.doi.org/10.1038/srep45032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359577/
https://www.ncbi.nlm.nih.gov/pubmed/28322340
http://dx.doi.org/10.1038/srep45032

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