A non-cell autonomous mouse model of CNS haemangioblastoma mediated by mutant KRAS

Haemangioblastoma is a rare malignancy of the CNS where vascular proliferation causes lesions due to endothelial propagation. We found that conditionally expressing mutant Kras, using Rag1-Cre, gave rise to CNS haemangioblastoma in the cortex and cerebellum in mice that present with highly vascular...

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Detalles Bibliográficos
Autores principales: Bao, Leyuan, Al-Assar, Osama, Drynan, Lesley F., Arends, Mark J., Tyers, Pam, Barker, Roger A., Rabbitts, Terence H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359595/
https://www.ncbi.nlm.nih.gov/pubmed/28322325
http://dx.doi.org/10.1038/srep44899

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359595/
https://www.ncbi.nlm.nih.gov/pubmed/28322325
http://dx.doi.org/10.1038/srep44899

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