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A non-cell autonomous mouse model of CNS haemangioblastoma mediated by mutant KRAS

Haemangioblastoma is a rare malignancy of the CNS where vascular proliferation causes lesions due to endothelial propagation. We found that conditionally expressing mutant Kras, using Rag1-Cre, gave rise to CNS haemangioblastoma in the cortex and cerebellum in mice that present with highly vascular...

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Detalles Bibliográficos
Autores principales:	Bao, Leyuan, Al-Assar, Osama, Drynan, Lesley F., Arends, Mark J., Tyers, Pam, Barker, Roger A., Rabbitts, Terence H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359595/ https://www.ncbi.nlm.nih.gov/pubmed/28322325 http://dx.doi.org/10.1038/srep44899

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