Tricyclic Antidepressants Promote Ceramide Accumulation to Regulate Collagen Production in Human Hepatic Stellate Cells

Activation of hepatic stellate cells (HSCs) in response to injury is a key step in hepatic fibrosis, and is characterized by trans-differentiation of quiescent HSCs to HSC myofibroblasts, which secrete extracellular matrix proteins responsible for the fibrotic scar. There are currently no therapies...

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Detalles Bibliográficos
Autores principales: Chen, Jennifer Y., Newcomb, Benjamin, Zhou, Chan, Pondick, Joshua V., Ghoshal, Sarani, York, Samuel R., Motola, Daniel L., Coant, Nicolas, Yi, Jae Kyo, Mao, Cungui, Tanabe, Kenneth K., Bronova, Irina, Berdyshev, Evgeny V., Fuchs, Bryan C., Hannun, Yusuf, Chung, Raymond T., Mullen, Alan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359599/
https://www.ncbi.nlm.nih.gov/pubmed/28322247
http://dx.doi.org/10.1038/srep44867

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