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Clinical utility of biomarkers of endothelial activation and coagulation for prognosis in HIV infection: A systematic review
Introduction: HIV infection is associated with vascular dysfunction and adverse cardiovascular outcomes. Our objective was to review the evidence regarding the clinical utility of endothelial activation and coagulation biomarkers for the prognosis of HIV-infected patients. Methods: We searched PubMe...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359730/ https://www.ncbi.nlm.nih.gov/pubmed/23732995 http://dx.doi.org/10.4161/viru.25221 |
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author | Graham, Susan M Mwilu, Regina Liles, W Conrad |
author_facet | Graham, Susan M Mwilu, Regina Liles, W Conrad |
author_sort | Graham, Susan M |
collection | PubMed |
description | Introduction: HIV infection is associated with vascular dysfunction and adverse cardiovascular outcomes. Our objective was to review the evidence regarding the clinical utility of endothelial activation and coagulation biomarkers for the prognosis of HIV-infected patients. Methods: We searched PubMed and Embase for publications using the keywords “HIV” or “HIV infection” and “endothelium” or “coagulation”. We reviewed reference lists and hand-searched for additional relevant articles. All clinical studies that enrolled non-pregnant, HIV-infected adults, measured biomarkers reflecting endothelial activation or coagulation, and prospectively evaluated their associations with vascular dysfunction or clinical outcomes were included. Results: Seventeen studies were identified that fulfilled the inclusion criteria, of which 11 investigated endothelial activation biomarkers and 12 investigated coagulation biomarkers. Biomarkers and outcomes varied widely across studies. Overall, published studies support an association between P-selectin and venous thromboembolism in HIV-infected patients, an association between tissue-type plasminogen activator and death, and associations between D-dimer and several clinical outcomes, including venous thromboembolism, cardiovascular disease, and all-cause mortality. Conclusions: Several studies have demonstrated associations between biomarkers of endothelial activation and coagulation and clinically important outcomes in HIV-1 infection. Additional large-scale prospective investigations to determine the utility of endothelial activation and coagulation biomarkers for risk stratification and prediction of adverse outcomes are clearly warranted. |
format | Online Article Text |
id | pubmed-5359730 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-53597302017-03-28 Clinical utility of biomarkers of endothelial activation and coagulation for prognosis in HIV infection: A systematic review Graham, Susan M Mwilu, Regina Liles, W Conrad Virulence Special Focus Review Introduction: HIV infection is associated with vascular dysfunction and adverse cardiovascular outcomes. Our objective was to review the evidence regarding the clinical utility of endothelial activation and coagulation biomarkers for the prognosis of HIV-infected patients. Methods: We searched PubMed and Embase for publications using the keywords “HIV” or “HIV infection” and “endothelium” or “coagulation”. We reviewed reference lists and hand-searched for additional relevant articles. All clinical studies that enrolled non-pregnant, HIV-infected adults, measured biomarkers reflecting endothelial activation or coagulation, and prospectively evaluated their associations with vascular dysfunction or clinical outcomes were included. Results: Seventeen studies were identified that fulfilled the inclusion criteria, of which 11 investigated endothelial activation biomarkers and 12 investigated coagulation biomarkers. Biomarkers and outcomes varied widely across studies. Overall, published studies support an association between P-selectin and venous thromboembolism in HIV-infected patients, an association between tissue-type plasminogen activator and death, and associations between D-dimer and several clinical outcomes, including venous thromboembolism, cardiovascular disease, and all-cause mortality. Conclusions: Several studies have demonstrated associations between biomarkers of endothelial activation and coagulation and clinically important outcomes in HIV-1 infection. Additional large-scale prospective investigations to determine the utility of endothelial activation and coagulation biomarkers for risk stratification and prediction of adverse outcomes are clearly warranted. Taylor & Francis 2013-06-24 /pmc/articles/PMC5359730/ /pubmed/23732995 http://dx.doi.org/10.4161/viru.25221 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Special Focus Review Graham, Susan M Mwilu, Regina Liles, W Conrad Clinical utility of biomarkers of endothelial activation and coagulation for prognosis in HIV infection: A systematic review |
title | Clinical utility of biomarkers of endothelial activation and coagulation for prognosis in HIV infection: A systematic review |
title_full | Clinical utility of biomarkers of endothelial activation and coagulation for prognosis in HIV infection: A systematic review |
title_fullStr | Clinical utility of biomarkers of endothelial activation and coagulation for prognosis in HIV infection: A systematic review |
title_full_unstemmed | Clinical utility of biomarkers of endothelial activation and coagulation for prognosis in HIV infection: A systematic review |
title_short | Clinical utility of biomarkers of endothelial activation and coagulation for prognosis in HIV infection: A systematic review |
title_sort | clinical utility of biomarkers of endothelial activation and coagulation for prognosis in hiv infection: a systematic review |
topic | Special Focus Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359730/ https://www.ncbi.nlm.nih.gov/pubmed/23732995 http://dx.doi.org/10.4161/viru.25221 |
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