TRIM8 restores p53 tumour suppressor function by blunting N-MYC activity in chemo-resistant tumours

BACKGROUND: TRIM8 plays a key role in controlling the p53 molecular switch that sustains the transcriptional activation of cell cycle arrest genes and response to chemotherapeutic drugs. The mechanisms that regulate TRIM8, especially in cancers like clear cell Renal Cell Carcinoma (ccRCC) and colore...

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Detalles Bibliográficos
Autores principales: Mastropasqua, Francesca, Marzano, Flaviana, Valletti, Alessio, Aiello, Italia, Di Tullio, Giuseppe, Morgano, Annalisa, Liuni, Sabino, Ranieri, Elena, Guerrini, Luisa, Gasparre, Giuseppe, Sbisà, Elisabetta, Pesole, Graziano, Moschetta, Antonio, Caratozzolo, Mariano Francesco, Tullo, Apollonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359838/
https://www.ncbi.nlm.nih.gov/pubmed/28327152
http://dx.doi.org/10.1186/s12943-017-0634-7

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