Co/NHPI-mediated aerobic oxygenation of benzylic C–H bonds in pharmaceutically relevant molecules

A simple cobalt(ii)/N-hydroxyphthalimide catalyst system has been identified for selective conversion of benzylic methylene groups in pharmaceutically relevant (hetero)arenes to the corresponding (hetero)aryl ketones. The radical reaction pathway tolerates electronically diverse benzylic C–H bonds,...

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Detalles Bibliográficos
Autores principales: Hruszkewycz, Damian P., Miles, Kelsey C., Thiel, Oliver R., Stahl, Shannon S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359875/
https://www.ncbi.nlm.nih.gov/pubmed/28451270
http://dx.doi.org/10.1039/c6sc03831j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359875/
https://www.ncbi.nlm.nih.gov/pubmed/28451270
http://dx.doi.org/10.1039/c6sc03831j

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