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The allosteric AKT inhibitor MK2206 shows a synergistic interaction with chemotherapy and radiotherapy in glioblastoma spheroid cultures

BACKGROUND: Glioblastoma multiforme (GBM) is the most common, invasive and deadly primary type of malignant brain tumor. The Phosphatidylinositol-3-Kinase/AKT (PI3K/AKT) pathway is highly active in GBM and has been associated with increased survival and resistance to therapy. The aim of this study i...

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Detalles Bibliográficos
Autores principales:	Narayan, Ravi S., Fedrigo, Carlos A., Brands, Eelke, Dik, Rogier, Stalpers, Lukas J.A., Baumert, Brigitta G., Slotman, Ben J., Westerman, Bart A., Peters, Godefridus J., Sminia, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359921/ https://www.ncbi.nlm.nih.gov/pubmed/28320338 http://dx.doi.org/10.1186/s12885-017-3193-9

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