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OX40 signaling is involved in the autoactivation of CD4(+)CD28(−) T cells and contributes to the pathogenesis of autoimmune arthritis

BACKGROUND: CD4(+)CD28(−) T cells exhibit autoreactive potential in autoimmune disorders, including rheumatoid arthritis (RA). It is not well known which costimulator functions as an alternative second signal in the activation of this subset after CD28 expression is downregulated. Tumor necrosis fac...

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Detalles Bibliográficos
Autores principales:	Jiang, Juean, Liu, Cuiping, Liu, Mi, Shen, Yu, Hu, Xiaohan, Wang, Qin, Wu, Jian, Wu, Min, Fang, Qi, Zhang, Xueguang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359925/ https://www.ncbi.nlm.nih.gov/pubmed/28320444 http://dx.doi.org/10.1186/s13075-017-1261-9

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