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Association of the lupus low disease activity state (LLDAS) with health-related quality of life in a multinational prospective study
BACKGROUND: Systemic lupus erythematosus (SLE) is associated with significant impairment of health-related quality of life (HR-QoL). Recently, meeting a definition of a lupus low disease activity state (LLDAS), analogous to low disease activity in rheumatoid arthritis, was preliminarily validated as...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359963/ https://www.ncbi.nlm.nih.gov/pubmed/28320433 http://dx.doi.org/10.1186/s13075-017-1256-6 |
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author | Golder, Vera Kandane-Rathnayake, Rangi Hoi, Alberta Yik-Bun Huq, Molla Louthrenoo, Worawit An, Yuan Li, Zhan Guo Luo, Shue Fen Sockalingam, Sargunan Lau, Chak Sing Mok, Mo Yin Lateef, Aisha Franklyn, Kate Morton, Susan Navarra, Sandra Teresa V. Zamora, Leonid Wu, Yeong-Jian Hamijoyo, Laniyati Chan, Madelynn O’Neill, Sean Goldblatt, Fiona Nikpour, Mandana Morand, Eric Francis |
author_facet | Golder, Vera Kandane-Rathnayake, Rangi Hoi, Alberta Yik-Bun Huq, Molla Louthrenoo, Worawit An, Yuan Li, Zhan Guo Luo, Shue Fen Sockalingam, Sargunan Lau, Chak Sing Mok, Mo Yin Lateef, Aisha Franklyn, Kate Morton, Susan Navarra, Sandra Teresa V. Zamora, Leonid Wu, Yeong-Jian Hamijoyo, Laniyati Chan, Madelynn O’Neill, Sean Goldblatt, Fiona Nikpour, Mandana Morand, Eric Francis |
author_sort | Golder, Vera |
collection | PubMed |
description | BACKGROUND: Systemic lupus erythematosus (SLE) is associated with significant impairment of health-related quality of life (HR-QoL). Recently, meeting a definition of a lupus low disease activity state (LLDAS), analogous to low disease activity in rheumatoid arthritis, was preliminarily validated as associated with protection from damage accrual. The LLDAS definition has not been previously evaluated for association with patient-reported outcomes. The objective of this study was to determine whether LLDAS is associated with better HR-QoL, and examine predictors of HR-QoL, in a large multiethnic, multinational cohort of patients with SLE. METHODS: HR-QoL was measured using the Medical Outcomes Study 36-item short form health survey (SF-36v2) in a prospective study of 1422 patients. Disease status was measured using the SLE disease activity index (SLEDAI-2 K), physician global assessment (PGA) and LLDAS. RESULTS: Significant differences in SF-36 domain scores were found between patients stratified by ethnic group, education level and damage score, and with the presence of active musculoskeletal or cutaneous manifestations. In multiple linear regression analysis, Asian ethnicity (p < 0.001), a higher level of education (p < 0.001), younger age (p < 0.001) and shorter disease duration (p < 0.01) remained significantly associated with better physical component scores (PCS). Musculoskeletal disease activity (p < 0.001) was negatively associated with PCS, and cutaneous activity (p = 0.04) was negatively associated with mental component scores (MCS). Patients in LLDAS had better PCS (p < 0.001) and MCS (p < 0.001) scores and significantly better scores in multiple individual SF-36 domain scores. Disease damage was associated with worse PCS (p < 0.001), but not MCS scores. CONCLUSIONS: Ethnicity, education, disease damage and specific organ involvement impacts HR-QoL in SLE. Attainment of LLDAS is associated with better HR-QoL. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13075-017-1256-6) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-5359963 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-53599632017-03-22 Association of the lupus low disease activity state (LLDAS) with health-related quality of life in a multinational prospective study Golder, Vera Kandane-Rathnayake, Rangi Hoi, Alberta Yik-Bun Huq, Molla Louthrenoo, Worawit An, Yuan Li, Zhan Guo Luo, Shue Fen Sockalingam, Sargunan Lau, Chak Sing Mok, Mo Yin Lateef, Aisha Franklyn, Kate Morton, Susan Navarra, Sandra Teresa V. Zamora, Leonid Wu, Yeong-Jian Hamijoyo, Laniyati Chan, Madelynn O’Neill, Sean Goldblatt, Fiona Nikpour, Mandana Morand, Eric Francis Arthritis Res Ther Research Article BACKGROUND: Systemic lupus erythematosus (SLE) is associated with significant impairment of health-related quality of life (HR-QoL). Recently, meeting a definition of a lupus low disease activity state (LLDAS), analogous to low disease activity in rheumatoid arthritis, was preliminarily validated as associated with protection from damage accrual. The LLDAS definition has not been previously evaluated for association with patient-reported outcomes. The objective of this study was to determine whether LLDAS is associated with better HR-QoL, and examine predictors of HR-QoL, in a large multiethnic, multinational cohort of patients with SLE. METHODS: HR-QoL was measured using the Medical Outcomes Study 36-item short form health survey (SF-36v2) in a prospective study of 1422 patients. Disease status was measured using the SLE disease activity index (SLEDAI-2 K), physician global assessment (PGA) and LLDAS. RESULTS: Significant differences in SF-36 domain scores were found between patients stratified by ethnic group, education level and damage score, and with the presence of active musculoskeletal or cutaneous manifestations. In multiple linear regression analysis, Asian ethnicity (p < 0.001), a higher level of education (p < 0.001), younger age (p < 0.001) and shorter disease duration (p < 0.01) remained significantly associated with better physical component scores (PCS). Musculoskeletal disease activity (p < 0.001) was negatively associated with PCS, and cutaneous activity (p = 0.04) was negatively associated with mental component scores (MCS). Patients in LLDAS had better PCS (p < 0.001) and MCS (p < 0.001) scores and significantly better scores in multiple individual SF-36 domain scores. Disease damage was associated with worse PCS (p < 0.001), but not MCS scores. CONCLUSIONS: Ethnicity, education, disease damage and specific organ involvement impacts HR-QoL in SLE. Attainment of LLDAS is associated with better HR-QoL. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13075-017-1256-6) contains supplementary material, which is available to authorized users. BioMed Central 2017-03-20 2017 /pmc/articles/PMC5359963/ /pubmed/28320433 http://dx.doi.org/10.1186/s13075-017-1256-6 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Golder, Vera Kandane-Rathnayake, Rangi Hoi, Alberta Yik-Bun Huq, Molla Louthrenoo, Worawit An, Yuan Li, Zhan Guo Luo, Shue Fen Sockalingam, Sargunan Lau, Chak Sing Mok, Mo Yin Lateef, Aisha Franklyn, Kate Morton, Susan Navarra, Sandra Teresa V. Zamora, Leonid Wu, Yeong-Jian Hamijoyo, Laniyati Chan, Madelynn O’Neill, Sean Goldblatt, Fiona Nikpour, Mandana Morand, Eric Francis Association of the lupus low disease activity state (LLDAS) with health-related quality of life in a multinational prospective study |
title | Association of the lupus low disease activity state (LLDAS) with health-related quality of life in a multinational prospective study |
title_full | Association of the lupus low disease activity state (LLDAS) with health-related quality of life in a multinational prospective study |
title_fullStr | Association of the lupus low disease activity state (LLDAS) with health-related quality of life in a multinational prospective study |
title_full_unstemmed | Association of the lupus low disease activity state (LLDAS) with health-related quality of life in a multinational prospective study |
title_short | Association of the lupus low disease activity state (LLDAS) with health-related quality of life in a multinational prospective study |
title_sort | association of the lupus low disease activity state (lldas) with health-related quality of life in a multinational prospective study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359963/ https://www.ncbi.nlm.nih.gov/pubmed/28320433 http://dx.doi.org/10.1186/s13075-017-1256-6 |
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