The function of myostatin in the regulation of fat mass in mammals

Myostatin (MSTN), also referred to as growth and differentiation factor-8, is a protein secreted in muscle tissues. Researchers believe that its primary function is in negatively regulating muscle because a mutation in its coding region can lead to the famous double muscle trait in cattle. Muscle an...

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Autores principales: Deng, Bing, Zhang, Feng, Wen, Jianghui, Ye, Shengqiang, Wang, Lixia, Yang, Yu, Gong, Ping, Jiang, Siwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360019/
https://www.ncbi.nlm.nih.gov/pubmed/28344633
http://dx.doi.org/10.1186/s12986-017-0179-1
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author Deng, Bing
Zhang, Feng
Wen, Jianghui
Ye, Shengqiang
Wang, Lixia
Yang, Yu
Gong, Ping
Jiang, Siwen
author_facet Deng, Bing
Zhang, Feng
Wen, Jianghui
Ye, Shengqiang
Wang, Lixia
Yang, Yu
Gong, Ping
Jiang, Siwen
author_sort Deng, Bing
collection PubMed
description Myostatin (MSTN), also referred to as growth and differentiation factor-8, is a protein secreted in muscle tissues. Researchers believe that its primary function is in negatively regulating muscle because a mutation in its coding region can lead to the famous double muscle trait in cattle. Muscle and adipose tissue develop from the same mesenchymal stem cells, and researchers have found that MSTN is expressed in fat tissues and plays a key role in adipogenesis. Interestingly, MSTN can exert a dual function, either inhibiting or promoting adipogenesis, according to the situation. Due to its potential function in controlling body fat mass, MSTN has attracted the interest of researchers. In this review, we explore its function in regulating adipogenesis in mammals, including preadipocytes, multipotent stem cells and fat mass.
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spelling pubmed-53600192017-03-24 The function of myostatin in the regulation of fat mass in mammals Deng, Bing Zhang, Feng Wen, Jianghui Ye, Shengqiang Wang, Lixia Yang, Yu Gong, Ping Jiang, Siwen Nutr Metab (Lond) Review Myostatin (MSTN), also referred to as growth and differentiation factor-8, is a protein secreted in muscle tissues. Researchers believe that its primary function is in negatively regulating muscle because a mutation in its coding region can lead to the famous double muscle trait in cattle. Muscle and adipose tissue develop from the same mesenchymal stem cells, and researchers have found that MSTN is expressed in fat tissues and plays a key role in adipogenesis. Interestingly, MSTN can exert a dual function, either inhibiting or promoting adipogenesis, according to the situation. Due to its potential function in controlling body fat mass, MSTN has attracted the interest of researchers. In this review, we explore its function in regulating adipogenesis in mammals, including preadipocytes, multipotent stem cells and fat mass. BioMed Central 2017-03-21 /pmc/articles/PMC5360019/ /pubmed/28344633 http://dx.doi.org/10.1186/s12986-017-0179-1 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Deng, Bing
Zhang, Feng
Wen, Jianghui
Ye, Shengqiang
Wang, Lixia
Yang, Yu
Gong, Ping
Jiang, Siwen
The function of myostatin in the regulation of fat mass in mammals
title The function of myostatin in the regulation of fat mass in mammals
title_full The function of myostatin in the regulation of fat mass in mammals
title_fullStr The function of myostatin in the regulation of fat mass in mammals
title_full_unstemmed The function of myostatin in the regulation of fat mass in mammals
title_short The function of myostatin in the regulation of fat mass in mammals
title_sort function of myostatin in the regulation of fat mass in mammals
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360019/
https://www.ncbi.nlm.nih.gov/pubmed/28344633
http://dx.doi.org/10.1186/s12986-017-0179-1
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