Safety, tumor trafficking and immunogenicity of chimeric antigen receptor (CAR)-T cells specific for TAG-72 in colorectal cancer

BACKGROUND: T cells engineered to express chimeric antigen receptors (CARs) have established efficacy in the treatment of B-cell malignancies, but their relevance in solid tumors remains undefined. Here we report results of the first human trials of CAR-T cells in the treatment of solid tumors perfo...

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Detalles Bibliográficos
Autores principales: Hege, Kristen M., Bergsland, Emily K., Fisher, George A., Nemunaitis, John J., Warren, Robert S., McArthur, James G., Lin, Andy A., Schlom, Jeffrey, June, Carl H., Sherwin, Stephen A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360066/
https://www.ncbi.nlm.nih.gov/pubmed/28344808
http://dx.doi.org/10.1186/s40425-017-0222-9

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