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Severe pulmonary hypertension in aging female apolipoprotein E-deficient mice is rescued by estrogen replacement therapy

BACKGROUND: Apolipoprotein E (ApoE) is a multifunctional protein, and its deficiency leads to the development of atherosclerosis in mice. Patients with pulmonary hypertension (PH) have reduced expression of ApoE in lung tissue. ApoE is known to inhibit endothelial and smooth muscle cell proliferatio...

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Detalles Bibliográficos
Autores principales:	Umar, Soban, Partow-Navid, Rod, Ruffenach, Gregoire, Iorga, Andrea, Moazeni, Shayan, Eghbali, Mansoureh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360087/ https://www.ncbi.nlm.nih.gov/pubmed/28344760 http://dx.doi.org/10.1186/s13293-017-0129-7

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