Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score

BACKGROUND: Identifying individuals at risk for developing Alzheimer disease (AD) is of utmost importance. Although genetic studies have identified AD-associated SNPs in APOE and other genes, genetic information has not been integrated into an epidemiological framework for risk prediction. METHODS A...

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Detalles Bibliográficos
Autores principales: Desikan, Rahul S., Fan, Chun Chieh, Wang, Yunpeng, Schork, Andrew J., Cabral, Howard J., Cupples, L. Adrienne, Thompson, Wesley K., Besser, Lilah, Kukull, Walter A., Holland, Dominic, Chen, Chi-Hua, Brewer, James B., Karow, David S., Kauppi, Karolina, Witoelar, Aree, Karch, Celeste M., Bonham, Luke W., Yokoyama, Jennifer S., Rosen, Howard J., Miller, Bruce L., Dillon, William P., Wilson, David M., Hess, Christopher P., Pericak-Vance, Margaret, Haines, Jonathan L., Farrer, Lindsay A., Mayeux, Richard, Hardy, John, Goate, Alison M., Hyman, Bradley T., Schellenberg, Gerard D., McEvoy, Linda K., Andreassen, Ole A., Dale, Anders M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360219/
https://www.ncbi.nlm.nih.gov/pubmed/28323831
http://dx.doi.org/10.1371/journal.pmed.1002258

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