Cargando…

Bupropion for the treatment of apathy in Huntington’s disease: A multicenter, randomised, double-blind, placebo-controlled, prospective crossover trial

OBJECTIVE: To evaluate the efficacy and safety of bupropion in the treatment of apathy in Huntington’s disease (HD). METHODS: In this phase 2b multicentre, double-blind, placebo-controlled crossover trial, individuals with HD and clinical signs of apathy according to the Structured Clinical Intervie...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gelderblom, Harald, Wüstenberg, Torsten, McLean, Tim, Mütze, Lisanne, Fischer, Wilhelm, Saft, Carsten, Hoffmann, Rainer, Süssmuth, Sigurd, Schlattmann, Peter, van Duijn, Erik, Landwehrmeyer, Bernhard, Priller, Josef
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360242/ https://www.ncbi.nlm.nih.gov/pubmed/28323838 http://dx.doi.org/10.1371/journal.pone.0173872

Ejemplares similares

Bupropion for the Treatment of Apathy in Alzheimer Disease: A Randomized Clinical Trial
por: Maier, Franziska, et al.
Publicado: (2020)

Prodromal Huntington Disease as a Model for Functional Compensation of Early Neurodegeneration
por: Malejko, Kathrin, et al.
Publicado: (2014)

Clinical Management of Neuropsychiatric Symptoms of Huntington Disease: Expert-Based Consensus Guidelines on Agitation, Anxiety, Apathy, Psychosis and Sleep Disorders
por: Anderson, Karen E., et al.
Publicado: (2018)

Symptomatic treatment options for Huntington’s disease (guidelines of the German Neurological Society)
por: Saft, Carsten, et al.
Publicado: (2023)

Assessment of Depression, Anxiety and Apathy in Prodromal and Early Huntington Disease
por: Vaccarino, Anthony L, et al.
Publicado: (2011)

Stability effects on results of diffusion tensor imaging analysis by reduction of the number of gradient directions due to motion artifacts: an application to presymptomatic Huntington’s disease
por: Müller, Hans-Peter, et al.
Publicado: (2012)

Apathy and atrophy of subcortical brain structures in Huntington's disease: A two-year follow-up study
por: Baake, Verena, et al.
Publicado: (2018)

Evaluating multicenter DTI data in Huntington's disease on site specific effects: An ex post facto approach()
por: Müller, Hans-Peter, et al.
Publicado: (2013)

Stereoselective Metabolism of Bupropion to OH-bupropion, Threohydrobupropion, Erythrohydrobupropion, and 4′-OH-bupropion in vitro
por: Sager, Jennifer E., et al.
Publicado: (2016)

White matter cortico-striatal tracts predict apathy subtypes in Huntington's disease
por: De Paepe, Audrey E., et al.
Publicado: (2019)

Imbalanced basal ganglia connectivity is associated with motor deficits and apathy in Huntington’s disease
por: Nair, Akshay, et al.
Publicado: (2021)

Disordered Decision Making: A Cognitive Framework for Apathy and Impulsivity in Huntington's Disease
por: Morris, Lee‐Anne, et al.
Publicado: (2022)

Cognitive processes of apathy in Huntington’s disease show high sensitivity to disease progression
por: Hare, Emily, et al.
Publicado: (2022)

Impact of the control for corrupted diffusion tensor imaging data in comparisons at the group level: an application in Huntington disease
por: Müller, Hans-Peter, et al.
Publicado: (2014)

Naltrexone/Bupropion: Contrave®; Naltrexone SR/Bupropion SR
Publicado: (2012)

NMDA receptor gene variations as modifiers in Huntington disease: a replication study
por: Saft, Carsten, et al.
Publicado: (2011)

Hyponatremia Associated with Bupropion
por: Kim, Chang Seong, et al.
Publicado: (2011)

Combining Literature Review With a Ground Truth Approach for Diagnosing Huntington's Disease Phenocopy
por: Nguyen, Quang Tuan Rémy, et al.
Publicado: (2022)

Resurrection of sildenafil: potential for Huntington’s Disease, too?
por: Achenbach, Jannis, et al.
Publicado: (2022)

Error Processing in Huntington's Disease
por: Beste, Christian, et al.
Publicado: (2006)

Corrigendum: Combining Literature Review With a Ground Truth Approach for Diagnosing Huntington's Disease Phenocopy
por: Nguyen, Quang Tuan Rémy, et al.
Publicado: (2022)

The Role of the Immune System in Huntington's Disease
por: Ellrichmann, Gisa, et al.
Publicado: (2013)

Music perception and movement deterioration in Huntington’s disease
por: Beste, Christian, et al.
Publicado: (2011)

Distinct Subtypes of Apathy Revealed by the Apathy Motivation Index
por: Ang, Yuen-Siang, et al.
Publicado: (2017)

Apathy in Parkinson’s Disease: Defining the Park Apathy Subtype
por: De Waele, Ségolène, et al.
Publicado: (2022)

Observing Huntington’s Disease: the European Huntington’s Disease Network’s REGISTRY
por: Orth, Michael, et al.
Publicado: (2011)

Can bupropion unmask psychosis
por: Grover, Sandeep, et al.
Publicado: (2009)

Bupropion-Induced Erythema Multiforme
por: Evrensel, Alper, et al.
Publicado: (2015)

Tardive Dyskinesia Associated with Bupropion
por: Tuman, Taha Can, et al.
Publicado: (2017)

Bupropion-Induced Severe Leukocytosis
por: Jolly, Taranjeet S, et al.
Publicado: (2020)

Erythrodermic Psoriasis Exacerbated by Bupropion
por: Foss, Michael G, et al.
Publicado: (2021)

Differential diagnosis of chorea (guidelines of the German Neurological Society)
por: Saft, Carsten, et al.
Publicado: (2023)

Origins of Apathy
por: Mitchell, Alexander
Publicado: (1970)

Apathy or Activity?
por: Slater, Robert
Publicado: (1968)

Pain and apathy
por: Bahia, Valéria Santoro
Publicado: (2008)

Treatment of Irritability in Huntington’s Disease
por: van Duijn, Erik
Publicado: (2010)

Phonatory Dysfunction as a Preclinical Symptom of Huntington Disease
por: Rusz, Jan, et al.
Publicado: (2014)

Differential Diagnosis of Chorea—HIV Infection Delays Diagnosis of Huntington’s Disease by Years
por: Achenbach, Jannis, et al.
Publicado: (2021)

Oral and dental health in Huntington‘s disease - an observational study
por: Saft, Carsten, et al.
Publicado: (2013)

Bupropion hydrobromide propanol hemisolvate
por: Liu, Min, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_1po1vkdo1pi5cddhkkgjfsnfrj